NSAIDS and Immunosuppressants

Question 1

What are the two major toxicities of immunosuppressants?

• increased risk of nephrotoxicity and bleeding
• increased risk of hypertension and hirsutism
• increased risk of hepatotoxicity and renal damage
• increased risk of cancer and increased risk of infection

Answer 1

increased risk of cancer and increased risk of infection

Question 2

Which of the following statements is correct? Paracetamol:

• produces a toxic metabolite in acute over, leading to liver failure
• is used as an anti-inflammatory drug only
• is not effective for pain, headaches or fever
• increases prostaglandin synthesis

Answer 2

produces a toxic metabolite in acute over, leading to liver failure

Question 3

What are the side effects of glucocorticoids?

• decreased risk of infections
• increased risk of infections
• gigantism/acromegaly
• decreased appetite

Answer 3

increased risk of infections

Question 4

Cyclosporine is a key immunosuppressive agent use din organ transplantation. Which of the following options describes its potential adverse effects?

• hallucinations, hypertension, nephrotoxicity
• gum hyperplasia, hypertension, alopecia
• nephrotoxicity, hallucinations, hepatoxicity
• nephrotoxicity, hypertension, hepatoxicity

Answer 4

nephrotoxicity, hypertension, hepatoxicity

Question 5

Aspirin would be contraindicated in which of the following medical conditions?

• myalgia
• peptic ulcer
• rheumatoid arthritis
• myocardia infarction

Answer 5

peptic ulcer

Question 6

Which of the following actions is one of the “classic” pharmacological actions of NSAIDs?

• Anticoagulant action
• Teratogenic action
• Antipyretic action
• Hyperglycaemic action

Answer 6

Antipyretic action

Question 7

The mechanism of action of tacrolimus, also known as FK506, similar to which of the following drugs?

• Anakinra
• Cyclosporine
• Adalimumab
• Glucocorticoids

Answer 7

Cyclosporine

Question 8

The mechanism underlying how aspiring inhibits platelet aggregation is associated with:

• reduced synthesis of thromboxane (TXA2)
• reduced prostacyclin (PGI2)
• overall reduction in the metabolism of arachidonic acid
• reduced number of platelets

Answer 8

reduced synthesis of thromboxane (TXA2)