NSAIDs

Question 1

How does NSAIDs work ?

Answer 1

inhibits cox enzymes involved in prostaglandin synthesis
mild to moderate pain relief- 1st dose
Analgesic full effect: takes 1 week
Anti-inflammatory effect: takes 3 weeks

Question 2

Name selective cox-2 inhibitors ?

Answer 2

celecoxib
etorocoxib
parecoxib ( post-operative pain)

Question 3

Name non selective cox1/cox2 inhibitors ?

Answer 3

aspirin
diclofenac
ibuprofen
indometacin ( headache, GI disturbance, dizziness)
Mefenamic acid ( haemolytic anaemia, diarrhoea)
naproxen
piroxicam ( high risk of GI s/e, serious skin reactions)

Question 4

what reaction can topical NSAIDs cause ?

Answer 4

photosensitivity reactions especially with ketoprofen

Question 5

Which NSAIDs have highest risk of GI toxicity ?

Answer 5

ketoprofen
ketolorac
piroxicam

Question 6

Which NSAIDs have middle risk of GI toxicity ?

Answer 6

naproxen, diclofenac , indometacin

Question 7

Which NSAIDs have low risk of GI toxicity ?

Answer 7

ibuprofen

Question 8

Which NSAIDs have the lowest risk of GI toxicity ?

Answer 8

COX 2
celecoxib
etorocoxib
parecoxib

Question 9

Which NSAIDs have higher risk of Cardiovascular events ( stroke or MI ) ?

Answer 9

High dose ibuprofen 2.4g daily
dexibuprofen
cox-2 selective
diclofenac/aceclofenac