NSAIDS Flashcards
what is an Inflammatory Response?
response of body to injurious stimuli - includes wide variety of noxious agents.
Physical /Chemical Injury - Structural Strain - Infections- Many Diseases - Autoimmune Conditions
• Normally a protective response to reduce risk of further damage to organism
what are Autacoids? why r there so many types? what r their key feautres?
are biological factors which act like local hormones, have a brief duration, and act near the site of synthesis.
- 3ashan itha mshkla in the production of one, at least feeh others
SHORT HALF LIFE!
saves u from wasting any more energy than u need to in response to the injury
where r Eicosanoid classes derived from?
All Eicosanoid classes derived from Arachidonic Acid which is cleaved from cell membrane phospholipids
central role of arachidonic acid in prostanoid synthesis
which prostaglandin is most important in mediating inflammatory response?
COX-1
- roles of the PG made by COX-1
- half life?
COX-2
- when is it expressed?
- where is it found?
localized injury>COX 2 gets expressed on top of the COX 1,
what r most of the ADRs caused by NSAIDs result from?
bc of its contious expression! >> most ADRs caused by NSAIDs effects are due to COX-1 inhibition
Understand therapeutics / ADRs in terms of action on COX-1 and COX-2
- Main therapeutic effects of NSAIDs occur via COX-2 inhibition
- Due to its constitutive expression, most ADRs caused by NSAIDs effects are due to COX-1 inhibition
differences in COX-1 and COX-2 tunnel for selective inhibition by different NSAIDS
Prostaglandins: General Pharmacology
- binds to?
- how many types?
- actions?
Prostaglandins Specific For GPCRs
actions depend on PG recepter type
for PG E>> theres 4 types
Synergise with other autacoids – Bradykinin/Histamine
• PGs act as potent vasodilators - but don’t increase capillary permeability directly - synergise permeating effects of Bradykinin/Histamine
Often action includes synergising effects of other autacoids – to enhance the inflammatory signalling response!
eg. Bradykinin/Histamine
how do PGs act as potent vasodilators ?
don’t increase capillary permeability directly
BUT
byincreasing dilation> increased SA> more inflammatory mediators can pass through!
what induces the expression of COX 2?
Autacoid release also induces expression of COX-2
NSAIDs: Therapeutic Effects?
(main therapeutic effect?)