NSAIDS Flashcards

1
Q

what is an Inflammatory Response?

A

response of body to injurious stimuli - includes wide variety of noxious agents.

Physical /Chemical Injury - Structural Strain - Infections- Many Diseases - Autoimmune Conditions

• Normally a protective response to reduce risk of further damage to organism

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2
Q

what are Autacoids? why r there so many types? what r their key feautres?

A

are biological factors which act like local hormones, have a brief duration, and act near the site of synthesis.

  • 3ashan itha mshkla in the production of one, at least feeh others

SHORT HALF LIFE!

saves u from wasting any more energy than u need to in response to the injury

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3
Q

where r Eicosanoid classes derived from?

A

All Eicosanoid classes derived from Arachidonic Acid which is cleaved from cell membrane phospholipids

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4
Q

central role of arachidonic acid in prostanoid synthesis

which prostaglandin is most important in mediating inflammatory response?

A
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5
Q

COX-1

  • roles of the PG made by COX-1
  • half life?
A
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6
Q

COX-2

  • when is it expressed?
  • where is it found?
A

localized injury>COX 2 gets expressed on top of the COX 1,

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7
Q

what r most of the ADRs caused by NSAIDs result from?

A

bc of its contious expression! >> most ADRs caused by NSAIDs effects are due to COX-1 inhibition

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8
Q

Understand therapeutics / ADRs in terms of action on COX-1 and COX-2

A
  • Main therapeutic effects of NSAIDs occur via COX-2 inhibition
  • Due to its constitutive expression, most ADRs caused by NSAIDs effects are due to COX-1 inhibition
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9
Q

differences in COX-1 and COX-2 tunnel for selective inhibition by different NSAIDS

A
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10
Q

Prostaglandins: General Pharmacology

  • binds to?
  • how many types?
  • actions?
A

Prostaglandins Specific For GPCRs

actions depend on PG recepter type

for PG E>> theres 4 types

Synergise with other autacoids – Bradykinin/Histamine

• PGs act as potent vasodilators - but don’t increase capillary permeability directly - synergise permeating effects of Bradykinin/Histamine

Often action includes synergising effects of other autacoids – to enhance the inflammatory signalling response!

eg. Bradykinin/Histamine

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11
Q

how do PGs act as potent vasodilators ?

A

don’t increase capillary permeability directly

BUT

byincreasing dilation> increased SA> more inflammatory mediators can pass through!

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12
Q

what induces the expression of COX 2?

A

Autacoid release also induces expression of COX-2

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13
Q

NSAIDs: Therapeutic Effects?

(main therapeutic effect?)

A
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