NSAIDs Flashcards
What is COX 1 thought to regulate?
Constitutive prostaglandins: control of homeostasis, protective effects on gastric mucosa, platelet function, renal blood flow
Aspirin COX function?
COX 1 (Metabolite salicyclic acid is COX 1&2)
What is COX 2 thought to regulate?
Inducible prostaglandins: Pain, Inflammation, Fever
Phenylbutazone COX function?
Cox 1&2 (but is old and has the most GI side effects)
Ketoprofen COX function?
Preference for Cox1 (0.32 ratio) + Bradykinin inhibitor + inhibits some lipooxygenase pathways
Flunixin COX functions?
Cox 1&2 (less GI side effects)
Carprofen (Rimidyl) Cox function?
Slight Cox 2 preference (1.75-12 ratio) + PA2 inhibition
Meloxicam Cox function?
Slight Cox 2 preference (2.75-12 ratio) + inhibits PG2 synthesis
Deracoxib (Deramaxx) Cox function?
Cox 2 preference (12-37 ratio)
Fibrocoxib (Previcox) Cox function?
High Cox 2 preference (384 ratio)
Robenacoxib (Onsior) Cox function?
Cox 2 preference
Tepoxalin Cox function?
COX 1&2 + LOX (to reduce GI signs)
Piroxicam inhibitory function?
Prostaglandin inhibitor
Is Aspirin approved for use in animals?
No, only in humans
Aspirin side effects?
Irreversible binding to platelet COX 1 = inability for platelets to aggregate
What are side effects common to almost all NSAIDs?
Gastric and renal damage
Common use and approval for Phenylbutazone?
Approved in dogs & horses for joint pain and lamnitis
Common use and approval for Ketoprofen?
Approved in horses for arthritis and colic. Recommended in cats and dogs for acute pain, arthritis, and visceral pain. Comparable to opioids
Common uses and approval for Flunixin?
(Banamine) Approved in horses and cattle for colic & general pain
Common uses and approval for Carprofen?
(Rimidyl) Approved in dogs for arthritis and post op pain
Meloxicam uses and approvals?
(Metacam) Approved for use in dogs and cats for musculoskeletal DZ and post op pain. Chondroneutral unlike other NSAIDs.
Deracoxib uses and approvals?
(Deramaxx) Approved in dog for arthritis and post op pain
Firocoxib uses and approvals?
(Previcox) Approved in dogs and horse for arthritis and post op pain. Greater GI safety.
Tepoxalin uses and approvals?
(Zubrin) Approved in dogs for pain, inflammation, antipyretic. Supposedly less GI issues despite COX 1 inhibition due to also having leukotriene inhibition.
