NSAIDs

Question 1

What is COX 1 thought to regulate?

Answer 1

Constitutive prostaglandins: control of homeostasis, protective effects on gastric mucosa, platelet function, renal blood flow

Question 2

Aspirin COX function?

Answer 2

COX 1 (Metabolite salicyclic acid is COX 1&2)

Question 3

What is COX 2 thought to regulate?

Answer 3

Inducible prostaglandins: Pain, Inflammation, Fever

Question 4

Phenylbutazone COX function?

Answer 4

Cox 1&2 (but is old and has the most GI side effects)

Question 5

Ketoprofen COX function?

Answer 5

Preference for Cox1 (0.32 ratio) + Bradykinin inhibitor + inhibits some lipooxygenase pathways

Question 6

Flunixin COX functions?

Answer 6

Cox 1&2 (less GI side effects)

Question 7

Carprofen (Rimidyl) Cox function?

Answer 7

Slight Cox 2 preference (1.75-12 ratio) + PA2 inhibition

Question 8

Meloxicam Cox function?

Answer 8

Slight Cox 2 preference (2.75-12 ratio) + inhibits PG2 synthesis

Question 9

Deracoxib (Deramaxx) Cox function?

Answer 9

Cox 2 preference (12-37 ratio)

Question 10

Fibrocoxib (Previcox) Cox function?

Answer 10

High Cox 2 preference (384 ratio)

Question 11

Robenacoxib (Onsior) Cox function?

Answer 11

Cox 2 preference

Question 12

Tepoxalin Cox function?

Answer 12

COX 1&2 + LOX (to reduce GI signs)

Question 13

Piroxicam inhibitory function?

Answer 13

Prostaglandin inhibitor

Question 14

Is Aspirin approved for use in animals?

Answer 14

No, only in humans

Question 15

Aspirin side effects?

Answer 15

Irreversible binding to platelet COX 1 = inability for platelets to aggregate

Question 16

What are side effects common to almost all NSAIDs?

Answer 16

Gastric and renal damage

Question 17

Common use and approval for Phenylbutazone?

Answer 17

Approved in dogs & horses for joint pain and lamnitis

Question 18

Common use and approval for Ketoprofen?

Answer 18

Approved in horses for arthritis and colic. Recommended in cats and dogs for acute pain, arthritis, and visceral pain. Comparable to opioids

Question 19

Common uses and approval for Flunixin?

Answer 19

(Banamine) Approved in horses and cattle for colic & general pain

Question 20

Common uses and approval for Carprofen?

Answer 20

(Rimidyl) Approved in dogs for arthritis and post op pain

Question 21

Meloxicam uses and approvals?

Answer 21

(Metacam) Approved for use in dogs and cats for musculoskeletal DZ and post op pain. Chondroneutral unlike other NSAIDs.

Question 22

Deracoxib uses and approvals?

Answer 22

(Deramaxx) Approved in dog for arthritis and post op pain

Question 23

Firocoxib uses and approvals?

Answer 23

(Previcox) Approved in dogs and horse for arthritis and post op pain. Greater GI safety.

Question 24

Tepoxalin uses and approvals?

Answer 24

(Zubrin) Approved in dogs for pain, inflammation, antipyretic. Supposedly less GI issues despite COX 1 inhibition due to also having leukotriene inhibition.

Question 25

Robenacoxib uses and approvals?

Answer 25

(Onsior) Approved for short term use in cats and dogs for post-op pain.

Question 26

Piroxicam uses and approvals?

Answer 26

Should only use in humans - causes bad GI and nephro toxicity even at low doses. Enterohepatic recycling effect in dogs.