Drug Interactions

Question 1

Levetiracetam

Answer 1

Metabolized by entire body tissues - phenobarb will speed up clearance

Question 2

Phenobarb

Answer 2

Hepatic enzyme inducer - Speeds up body metabolism

Question 3

Cimetidine

Answer 3

Metabolism inhibitor - Lowers hepatic blood flow // Proteins in GI bind and impede absorbtion // Binds irreversibly with many drugs

Question 4

Chloramphenicol

Answer 4

Metabolism inhibiting antibiotic // Active renal tubular excretion - may compete with other drugs that excrete this way

Question 5

Ketoconazole

Answer 5

Metabolism inhibitor - Stops CP450

Question 6

Omeprazole

Answer 6

Antacid - changes stomach pH and thus changes absorption of certain drugs (Alkaline pH = higher absorption of weak bases, lower absorption of weak acids)

Question 7

Sucralfate

Answer 7

Stomach coating and chelating agent = inactivation of certain drugs/reduce absorption

Question 8

Diazepam

Answer 8

Precipitate forming with many drugs (sort-of exception: Ketamine) // Binds to IV lines // Light sensitivity

Question 9

KBr

Answer 9

Effects distrupted with high salt diets - Cl binds more readily to nerve channels than Br

Question 10

Digoxin

Answer 10

Competitive inhibition of Sodium-potassium ATPase pump - hyperkalemia reduces it’s effect