NSAIDs

Question 1

Celecoxib brand name

Answer 1

Celebrex

Question 2

Celecoxib Indication/dosage

Answer 2

S/S relief of osteoarthritis, rheumatoid arthritis, acute pain and dysmenorrhea: 100-200mg 1-2x/day

Question 3

Celecoxib mechanism

Answer 3

inhibits COX-2 to produce anti-inflammatory, analgesic, and antipyretic effects
little to no effect on COX-1 at therapeutic doses

Question 4

Celecoxib drug interactions

Answer 4

may decrease effectiveness of ACE-I’s
may increase plasma lithium level
fluconazole increases plasma levels
inhibits 2C9, caution with drugs metabolized this way, esp WARFARIN

Question 5

Celecoxib CI/precautions

Answer 5

CI: asthma, urticaria, or allergic-type reactions after sulfonamides, aspirin, or other NSAIDs, for treatment of peri-operative pain in CABG
may increase risk of serious CV thrombotic events, MI, stroke
Extreme caution in patients with history of ulcer disease or GI bleeding
Rare cases of GI bleeding
Avoid use in patients with advanced renal disease

Question 6

Celecoxibmonitoring

Answer 6

LFT’s periodically, may cause abnormalities

Question 7

Celecoxib pregnancy category

Answer 7

C

avoid during nursing and in late stages of pregnancy due to premature closure of ductus arteriosus

Question 8

Celecoxib ADRs

Answer 8

similar to placebo

diarrhea, dyspepsia, abdominal pain, flatulence, edema, sinusitis

Question 9

Celecoxib patient education

Answer 9

without regard to meals
report signs of ulceration and bleeding
avoid aspirin or like products without consultation