Narcotic Analgesics

Question 1

APAP/Codeine Brand Names

Answer 1

Tylenol #2, #3, #4, and Capital

Question 2

APAP/Codeine Brand Names

Answer 2

Tylenol #2, #3, #4, and Capital

Question 3

APAP/Codeine Indications/Dosage

Answer 3

Relief of Mild to Moderate pain
Adults: 1-2 tab q4h PRN (#2 or #3)
Children: 1-2tsp 3-4x/day
Relief of Moderate to Severe pain: 1 #4 tab q4h PRN

Question 4

APAP/Codeine Mechanism

Answer 4

APAP: inhibits prostaglandin synthesis in CNS, and blocks pain impulse generation
Codeine: weak mu-opiate receptor agonists, metabolized to morphine

Question 5

APAP/Codeine metabolism and excretion

Answer 5

Metabolized by CYP450 enzymes

Excreted through kidneys

Question 6

APAP/Codeine drug interactions

Answer 6

Other DNS depressants, alcohol: increase CNS depression

Hydantoins (phenytoin) and sulfinpyrazone (treats gout): increased risk of hepatotoxicity

Question 7

APAP/Codeine CI/Precautions

Answer 7

Increased ICP
Head injury
severe hepatic or renal impairment
prostatic hypertrophy or urethral stricture
presence of acute abdominal conditions

Question 8

APAP/Codeine Pregnancy category

Answer 8

C

Question 9

APAP/Codeine ADR’s

Answer 9

Dizziness, drowsiness, constipation, nausea, vomiting, excessive sweating

Question 10

APAP/Codeine Patient Education

Answer 10

May cause drowsiness, see how it affects you before planning on doing anything
Avoid alcohol
May take with food/milk to avoid GI upset
May be habit forming
Shake suspension well before dosing