NSAIDs

Question 1

PE: NSAIDs

Answer 1

analgesic, anti-pyretic, anti-inflammatory, anti-platelet

Question 2

Aspirin

Answer 2

acetyl salicylic acid–weak acid
can displace warfarin because it binds plasma proteins
ENZYME INHIBITOR: Cox inhibitor (inhibits PG metabolism)
Dangerous to treat a viral infection in children–>leads to Reyes syndrome

anti-pyretic: lowers fever
analgesic–treats pain because of less PGs
anti-inflammatory: no PG to initiate response
anti-clotting: irreversible inhibition of COX (no thromboxane)
-stop taking this before surgery.

Question 3

SE: aspirin

Answer 3

GI irritation (acid & decreased PG so less mucous)
Tinnitus
Don’t give to patients with clotting problems
Decreased kidney perfusion, inhibits labor, bronchospasm with asthma like effects

Question 4

Acetaminophen

Answer 4

not an NSAID
no anti-inflammatory, no anti-platelet
good for pain, bad for RA
less GI problems than aspirin
liver damage (too much glutathione)

Treat tylenol OD–N-acetylcysteine

Question 5

The NSAIDs

Answer 5

proprionic acid derivatives–“pro”
acetic acid derivatives–indometacin, tolmetin, sulindac
“NACs”
Cox-2 inhibitors–celecoxib

Question 6

indomethacin

Answer 6

NSAID-acetic acid derivatives
COX inhibitor
treats ductus arteriosus
SE: thrombocytopenia

Question 7

Celecoxib

Answer 7

SE: heartattack & stroke, affects PGI1 (vasodilator)

Question 8

How do steroids act

Answer 8

bind cytoplasmic receptor
dimerize
migrate to cell nucleus
Alters DNA transcription

Question 9

How do glucocorticoids act

Answer 9

induce lipocortin-1…inhibits synthesis of PGs

Question 10

SE: glucocorticoids

Answer 10

deficiency of cortisol--addisons disease
excess--cushings
adrenal suppression
decreased glucose uptake by muscle cells
moon face, m wasting, growth inhibition, cataracts, heart attack, peptic ulcers, psychosis, involuntary laughing or crying, poor wound healing, osteoporosis