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Pharmacology Section B > NSAIDS > Flashcards

NSAIDS Flashcards

1
Q

Type of NSAIDs

A

Non-selective NSAIDs
Cox-2 selective NSAIDs

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2
Q

Non-selective NSAIDs

A

Acetylsalicylic Acid (Aspirin)
Ibuprofen
Naproxen
Ketorolac

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3
Q

Cox-2 Selective NSAIDs

A

Celecoxib

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4
Q

NOT an NSAID

A

Acetaminophen

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5
Q

Acetaminophen

A

Pain reliever
Fever reducer

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6
Q

NSAIDs control what?

A

Mild to moderate pain

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7
Q

What kind of properties of NSAIDs

A

Analgesic (reduce pain)
Antipyretic (reduce fever)
Anti-inflammatory properties

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8
Q

Conditions to use NSAIDs

A

HA
Fever
Arthralgia
Myalgia
RA
OA

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9
Q

CV applications

A

Prophylactic use of low dose aspirin reduces risk of stroke and death from acute MI, stable and unstable angina

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10
Q

Acute pain

A

Temporary in nature
Usually goes away when cause of pain has been resolved

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11
Q

Chronic pain

A

Neuropathic pain
Results from nerve damage
Last for months
Often refractory to treatment

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12
Q

Inflammation

A

Body’s natural response to protect itself against the injurious agent

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13
Q

Inflammation is characterized by

A

Pain
Heat
Redness
Swelling
Loss of function (when chronic)

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14
Q

Analgesia

A

Insensibility to pain w/out a loss of consiousness

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15
Q

Nociceptor

A

Sensory receptor (pain receptor) that provides informatin about noxious input

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16
Q

Hyperalgesia

A

Increase sensitivity to noxious stimuli

17
Q

Allodynia

A

Exaggerated pain response to a normally non-noxious stimulus (light touch, bed sheets, clothing, etc.)

18
Q

NSAIDs
- periphery

A

Control mild to moderate pain

19
Q

NSAIDs
- centrally

A

Hypothalamus
Reduce fever

20
Q

What released following tissue damage

A

Potassium (K+)
Prostaglandins (PG)
Bradykinin (BK)

21
Q

Prostaglandins

A

Increase sensitivity of the sensory nerve terminal to bradykinin and other pain-producing substances

22
Q

Prostaglandins
- sensitize pain receptors to mechanical and thermal stimuli

A

By lowering the threshold of C-polymodal nociceptors

23
Q

Induces the release of substance P

A

Impulses generated in the stimulated terminal propagate not only to the SC, but also to the terminal branches

24
Q

At the blood vessels what does substance P do

A

Vasodilation and neurogenic edema

25
Q

What releases d/t SP

A

Histamine (H) from mast cells
Serotonin (5-HT) from platelets

26
Q

What do histamine and 5-HT do?

A

Raise the levels in the extracellular space causing secondary sensitization of nearby nociceptors

27
Q

Histamine and 5-HT
- Secondary sensitization

A

Gradual spread of hyperalgesia and/or tenderness

Pharmacology Section B (6 decks)

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