Dependence

Question 1

Types of dependence

Answer 1

Physical
Psychological

Question 2

Examples of physical

Answer 2

Infants born of addicted mothers show physical dependence and exhibit withdrawal symptoms if opioids are not administered

Question 3

Examples of psychological

Answer 3

Withdrawal symptoms produce a series of autonomic, motor, psychological responses that incapacitate the individual

Question 4

Administration of opiate agnoist does what

Answer 4

Immediately suppresses the withdrawal syndrome

Question 5

When do symptoms subside

Answer 5

within 5 days

Question 6

Withdrawal symptoms are less intense with

Answer 6

Methadone

Question 7

Methadone

Answer 7

Serves as the basis for its use in the detoxification of opiate addicts

Question 8

Opiate withdrawal
- Stage 1

Answer 8

Up to 8 hours
Anxiety
Drug craving

Question 9

Opiate withdrawal
- Stage 2

Answer 9

8-24 hours
Anxiety
Insomnia
GI disturbance
Rhinorrhea
Mydriasis
Diaphoresis

Question 10

Opiate withdrawal
- Stage 3

Answer 10

Tachycardia
Nausea, vomiting
Hypertension
Diarrhea
Fever
Chills
Tremors
Seizure
Muscle spasms

Question 11

Opiate antagonists

Answer 11

Used clinically for the treatment of opiate overdose (pupillary constriction, comatose state, and respiratory depression), compulsive use of opiates and alcoholism

Question 12

Opiate antagonists
- Naloxone

Answer 12

Parenteral use
Within 30s of IV injection of naloxone, the coma and respiratory depressant of high doses of opioid (such as heroin) overdose are reversed
Precipitates acute withdrawal symptoms in opioid abusers

Question 13

Opiate antagonists
- Naltrexone

Answer 13

A single oral dose blocks the effect of injected heroin for up to 48 h.
Hepatotoxic