NSAIDs

Question 1

An irreversible inhibitor and is particularly useful in preventing thrombotic events such as an MI or a stroke

Answer 1

Acetylsalicylic Acid (Aspirin)

Question 2

COX2 selective agent and is believed to have less potential to cause gastric ulceration

Answer 2

Celecoxib (Celebrex)

Question 3

a non-selective COX inhibitor with a good therapeutic profile

Answer 3

Ibuprofen (Motrin etc)

Question 4

What is the name for the following drugs? Dexamethasone, Hydrocortisone, Methylprednisolone, Prednisone

Answer 4

Corticosteroids

Question 5

How do corticosteroids work?

Answer 5

They regulate gene transcription. They reduce white blood cells and there is reduced arachidonic acid liberation, resulting in suppression of both prostaglandin and leukotriene synthesis.

Question 6

What are some side effects of corticosteroids?

Answer 6

Osteoporosis, susceptibility to infection, avascular bone necrosis

Question 7

What does prostaglandin E2 do?

Answer 7

Causes symptoms of inflammation: Edema, Pain, Redness, Warmth. Both COX inhibitors and corticosteroids inhibit prostaglandin synthesis.

Question 8

Blocks cyclooxygenase in the CNS, but not in the periphery. NOT anti-inflammatory. Both anti-pyretic and analgesic.

Answer 8

Acetaminophen (Tylenol)