NSAIDs

Question 1

NSAIDs

Answer 1

Ex:
Ibuprofen
Acetaminophen

Naproxen, Indomethacin, Ketorolac, Diclofenac, Aspirin, Celecoxib

MOA:
-inhibits COX –> decreased synthesis of PGs
-Phospholipids –(PLA2)–> Arachidonic Acids –(COX)–> PGs
NSAIDs ==| COX

AEs:
-Abdominal pain, ulcers, and GI bleeding
-decreased RBF, decreased GFR
-increased risk of bleeding, antithrombic effect (COX1 inhibition)
-increased risk of MI/stroke (COX2 inhibition)
-

Question 2

NSAIDS and COX

Answer 2

COX1 and COX2 (Nonselective COX inhibitors)
-Ibuprofen
-Naproxen
-Indomethacin
-Ketoralac
-Diclofenac
-Aspirin (325mg)

COX1 (COX-1 inhibitors)
-Aspirin (81mg)

COX2 (Selective (cele-) COX-2 inhibitors)
-Celecoxib

COX? (Unknown MOA)
Acetaminophen

Question 3

NSAIDs and AEs

Answer 3

COX1 and COX2 (Nonselective COX inhibitors)
-increased risk of CV thrombotic events

COX1 (COX-1 inhibitors)
-decreased risk of CV thrombotic events; used for CV benefits

COX2 (Selective (cele-) COX-2 inhibitors)
-increased risk of CV thrombotic events
-decreased GI AEs (compared to non-selective NSAIDs)

COX? (Unknown MOA)
-Hepatotoxic AEs