Neuropathic Pain

Question 1

Clonidine

Answer 1

MOA:
-a2-agonist

Use:
-Postoperative pain management
-neuropathic pain

AEs:
-hypotension
-sedation
-dry mouth (a2-Rs on parasympathetic postganglionic nerve terminals)

Question 2

Gabapentin

Answer 2

Antiepileptic Drugs

MOA:
-uncertain

Use:
-neuropathic pain
-seizures (adjunct therapy)

AEs:
-see anti-seizure lecture

Question 3

Carbamazepine, Phenytoin, Topiramate

Answer 3

Antiepileptic Drugs

MOA:
-prolong the inactivated state of Na-channels

Use:
-seizures
-neuropathic pain

AEs:
-see anti-seizure lecture

Question 4

Amitriptyline, Duloxetine

Answer 4

Antidepressants

MOA:
-inhibit NET and SERT (TCAs (e.g. amitriptyline)) also have many off-target effects

Use:
-antidepressants
-neuropathic pain

AEs:
-see antidepressant lecture

Question 5

Lidocaine

Answer 5

MOA:
-blocks VG Na-channels

Use:
-local anesthetic
-neuropathic pain (analgesic effects iccur at lower concentration than required for local anesthetics

AEs:
-see local anesthetic lecture