NSAIDs

Question 1

COX-1 functions?

Answer 1

Physiological functions/ house-keeping/maintenance

Question 2

COX-2 functions

Answer 2

Inflammatory mediators production

Question 3

COX-1 and COX-2 mechanism?

Answer 3

Catalyzes this rxn: Arachidonic acid -> cyclic endoperoxides (prostacyclins, prostaglandins, TXA2)

Question 4

Prostacyclin functions?

Answer 4

PGI2: dec platelet aggregation and dec vascular tone(vasodilation)

Question 5

Prostaglandins function?

Answer 5

PGE1: vasodilation, fever, pain
PGE2: uterine contraction
PGF2a: uterine contraction

Question 6

Thromboxane function?

Answer 6

TXA2: platelet aggregation and vasoconstriction

Question 7

Is paracetamol an NSAID?

Answer 7

No

Question 8

Paracetamol alt name

Answer 8

Acetaminophen

Question 9

Acetaminophen MOA

Answer 9

inhibits COX mostly in CNS

Question 10

Acetaminophen used instead of aspirin to avoid ___________

Answer 10

Reye syndrome in kids w viral infection

Question 11

Acetaminophen ADRs?

Answer 11

Hepatic necrosis by glutathione depletion

Question 12

Hepatic necrosis by acetaminophen antidote?

Answer 12

N-acetylcysteine

Question 13

Classification of NSAIDs?

Answer 13

Non selective COX Inhibitors (reversible and irreversible)

Selective COX-2 inhibitors

Question 14

Non selective COX inhibitors subclassification?

Answer 14

Irreversible: aspirin 
Reversible: 
ibuprofen
Naproxen
Indomethacin
Ketorolac
Diclofenac

Question 15

Aspirin MOA?

Answer 15

Inhibits COX 1 n 2 by Covalent acetylation

Affect lasts until new platelets are produced

Question 16

Aspirin clinical use?

Answer 16

Low dose- dec platelet aggregation
Intermediate dose- antipyretic and analgesic
High dose- anti inflammatory

Question 17

Aspirin ADRs?

Answer 17

Gastric ulceration
Tinnitus
Allergic rxn
Interstitial nephritis 
Mixed metabolic acidosis + resp alkalosis

Question 18

Aspirin OD treatment?

Answer 18

NaHCO3

Question 19

Reversible non selective COX inhibitors MOA?

Answer 19

Inhibits prostaglandin synthesis

Question 20

Reversible Non selective cox inhibitors clinical use?

Answer 20

Antipyretic
Analgesic
Anti inflammatory
Indomethacin to close PDA in kids

Question 21

NSAIDs (reversible non selective) ADRs?

Answer 21

Interstitial nephritis
Gastric ulcers
Renal ischemia
Aplastic anemia

Question 22

Selective cox 2 inhibitor?

Answer 22

Celecoxib

Question 23

Celecoxib MOA?

Answer 23

Only inhibits inflammation and pain

TXA2 and gastric mucosa spared

Question 24

Celecoxib clinical uses?

Answer 24

RHEUMATOID ARTHRITIS

OSTEOARTHRITIS

Question 25

Celecoxib ADRS?

Answer 25

Thrombosis
Sulfa allergy
Acute MI