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Anti-inflammatory > Gout And Rheumatoid Arthritis > Flashcards

Gout And Rheumatoid Arthritis Flashcards

1
Q

What is rheumatoid arthritis

A

Autoimmune and an inflammatory disease that attacks healthy joint cells (synovial) usually many at once

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2
Q

Cytokines responsible for joint destruction?

A

TNF-a
IL-1
IL-6
IL-17

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3
Q

Pathogenesis of RA?

A

Synovial membrane swollen > dec fluid > dec lubrication of ligaments and joints

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4
Q

Drugs for acute gout?

A

NSAIDs
Glucocorticoids
Colchicine

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5
Q

Drugs for chronic gout? (Preventive)

A

Allopurinol
Pegloticase
Febuxostat
Probenecid

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6
Q

Which drugs inhibit xanthine oxidase?

A

Allopurinol
febuxostat

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7
Q

Allopurinol also used in?

A

Lymphoma and leukemia to prevent tumor lysis associated urate nephropathy

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8
Q

Allopurinol ADR

A

Steven johnson syndrome in ppl with G6DP def

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9
Q

Pegloticase MOA?

A

Recombinant uricase catalyzing uric acid to allantoin (water sol)

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10
Q

Probenecid MOA

A

Inhibits uric acid reabsorption in PCT

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11
Q

Probenecid Interactions

A

Inhibits pencillin secretion

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12
Q

Probenecid ADR

A

uric acid calculi
Sulfa allergy

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13
Q

Salicylates (diuretics) in low doses may inhibits tubular secretion or reabsorption of uric acid

A

Secretion

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14
Q

Colchicine MOA

A

Inhibit microtubule polymerisation imparing chemotaxis and degranulation

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15
Q

Colchicine ADR

A

GI
Neuromyopathic
Myelo suppression
Nephrotoxicity

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16
Q

Glucocorticoids route

A

Oral
Intra articular
Parenteral

17
Q

Glucocorticoids ADR

A

Enhances osteoporosis
Stimulate diabetic tendencies

18
Q

________ contraindicated in gout?

A

Aspirin

19
Q

Therapy for RA

A

NSAIDs -for acute pain
Glucocorticoids -bridge to DMARDs
DMARDs -for late stage

20
Q

Drug that is gold standard for RA treatment

A

DMARDs

21
Q

Combination therapy for RA

A

2 or 3 DMARDs

22
Q

Double therapy for RA

A

MTX + any other

23
Q

Triple therapy for RA

A

MTX + sulphasalazine + hydroxycholorquine

24
Q

Types of DMARDs?

A

Biologic
Synthetic

25
Q

Biological DMARDs?

A

TNF-a inhibitors
Co-stimulant inhibitor
IL-6 inhibitors
B-cell depletors

26
Q

Synthetic DMARDs

A

Methotrexate
Sulphasalazine
Chloroquine, hydroxychloroquine
Leflunomide

27
Q

Chloroquine/hydroxychlroquine ADR

A

Ca deposition on retina

28
Q

Methotrexate (MTX) is an anti-_________ as well but taken in __________ doses

A

Anti neoplastic but taken in lower doses

29
Q

MTX ADRs?

A

Gastric irritation
Stomatitis
Pancytopenia

30
Q

Theres an increased risk of developing ________ due to MTX use

A

B-cell lymphoma/ secondary cancer

31
Q

Which DMARD is teratogenic

A

METHOTREXATE

32
Q

Course of MTX?

A

Once / week

33
Q

TNF-a inhibitors

A

Infliximab
Adalimumab
Golimumab

34
Q

Infliximab MOA

A

anti-TNF-a monoclonal antibody

35
Q

TNF-a ADRs

A

Predisposition to infections
Reactivation of latent TB
Drug induced Lupus

36
Q

Leflunomide MOA

A

Prevent pyrimidine synthesis
Suppression of T cell proliferation

37
Q

Leflunomide ADRs

A

Diarrhea
Hypertension
Hepatotoxic
Teratogenic

38
Q

Glucocorticoids inhibits which enz

A

Phospholipase A2

Anti-inflammatory (2 decks)

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