NRI lectures Flashcards

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1
Q

When sampling, why is info on age and sex distribution important?

A

For medically important species often longevity is the most important factor for vectorial capacity and often only females are vectors (blood feed).

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2
Q

What is teneral vs non teneral?

A

Teneral = have never fed
Non- teneral= have fed many times.

An arthropod stage where it is pale and soft bodied immediately after moulting (will have taken a blood meal prior to this).

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3
Q

What are the factors that differ that affect the behaviour of day active vs night active species (e.g. tsetse vs anopheles)?

A
  • Host motility/ quiescence- active vs passive seeking
  • Risk of predators e.g. birds etc
  • How much CO2 background there is
  • Visual cues
  • Wind speed- changes odour directionality
  • Desiccation risk
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4
Q

Descrive how baited warthog traps were used to see what tsetses were attracted to

A

Dead stuffed warthog had fewer flies landing

Live warthog had loads, visual cues suggested to be more important as opposed to visual cues here

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5
Q

Why are tsetses though to be attracted to blue at a long range?

A

Fur thought to reflect blue light- separates hosts from rocks and trees.

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6
Q

Describe cow experiements that suggested odour is more important than visual cues?

A

Cow with an incomplete ring around it and an electrified fence to see how many flies were coming from upwind vs downwind- expect more from the downwind side if odour is more important than visuals.

Cow in an underground pit with a fan blowing odour up. Lots of flies caught in the trap by the fan- odour very attractive even when they do not see the cow.

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7
Q

What can be used as a synthetic mix for host odour for tsetses?

A

Octenol, acetone, co2, phenols.

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8
Q

Why may human landing catches underestimate numbers?

A

Human decoy trap (human in tent with odour coming out far away next to a trap) caught 2000 mosquitos per night, humans cannot catch all of these themselves.

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9
Q

Why are anopheles gambiae the perfect vectors for malaria?

A
  • Very anthrophilic
  • Oviposition sites near humans- manmade containers and hoofprints
  • Rest near humans- endophilic
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10
Q

What is a factor that has one of the biggest effects on vectorial capacity?

A

Whether the vector consistently goes back to the same kind of animal- parasites and arboviruses often more species-specific so having a strong host preference means disease is more likely to spread between blood meals.

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11
Q

What are the main ways in which members of the anopheles gambiae complex differ from one another?

A
  • Host preference-cattle vs human feeding etc

- Endo or exophagic and philic

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12
Q

Tsetses are sympatric with which mosquito species and where are they found?

A

Anopheles arabiensis- in the tsetse belt because they are associated with the same environments.

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13
Q

What is the feeding preference of An arabiensis?

A

Is anthropophilic but prefers to bite outdoors so if there are peridomestic hosts outdoors like cows they will preferentially bite these.

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14
Q

How can rats cause different kinds of plague?

A

Bubonic and pneumonic from fleas. Pharyngeal plague endemic in Mozambique because rats are eaten.

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15
Q

How does the lifecycle of rats mean they can reach very high numbers quickly?

A

Can nurse a littler while being pregnantwith another- keep churning them out.
They reproduce on a monthly cycle with 6-12 babies per litter.

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16
Q

How was a civil war caused by rats in India?

A

Rats ate crops which led to debts and gang violence and an uprising due to famine.

17
Q

What is the WHO estimate of rodent related human disease?

A

400m cases.

18
Q

What is the prognosis of leptospirosis?

A

Can be 40% fatality with severe forms but often has lower mortality but is chronic.

19
Q

How is leptospirosis transmitted?

A

Bacterial disease passing through broken skin from water or soil contaminated with animal URINE. The spirochete burrows through the weakened skin. It has seasonal transmission with increases with rainfall and cyclones.

20
Q

How does leptospirosis present?

A

Haemorrhagic fever and multi organ failure.

21
Q

How do rats aid the spread of rickettsia? Which types?

A

Murine and scrub typhus.

Rats are reservoirs despite being tick and flea borne.

22
Q

How do rodents aid in leishmania disease transmission?

A

Are rodent reservoirs.

23
Q

How are arenaviruses maintained by rodents/?

A

Coevolution has meant that rodents maintain reservoirs of particular species. May be due to competition of viruses in the same host.

24
Q

Where is lassa virus distributed?

A

Mainly west and central Africa.

25
Q

How does lassa get transmitted?

A

Primary transmission between rats and humans then secondary transmission between humans and humans.

Transmission may be aerosol (rodent cough), from urine or via contaminated surfaces but not sure.

26
Q

How does lassa present?

A

Severe haemorrhagic fever with poor treatment and outcome with survivors often becoming deaf, leading to social exclusion.

27
Q

How is hantavirus transmitted?

A

Through inhalation of dry faecal material. COmmon in Scandinavian saunas where wood is burnt for the heat and inhaled.

28
Q

Hantavirus presentation?

A

Non specific fever, muscle aches and malaise. Some hantaviruses can cause haemorrhagic fever with renal syndrome.

29
Q

What are the different presentations of plague? What are they caused by?

A

All caused by Y pestis.
Bubonic- associated with septicemia and swollen lymph nodes and buboes with fleas use for transmission.

Pneumonic- rapidly fatal- cough up aeresol blood.

Septicemic- gangrene of nose, feet, face and hands.

30
Q

How are rats a reservoir of plague? How do rodent numbers affect the plague?

A

It does not kill rats so they are a reservoir and have urban and wild cycles in rodents.
High rodent densities drive the plague- above a density of 0.5 we need to start worrying and deploying control measures.

31
Q

How is plague controlled?

A
  • Insecticide to kill fleas (most are now insecticide-resistant)
  • Clean environment and treat person
32
Q

How and why do rainfall and temperature affect plague?

A

Increase in temperature and rainfall increases the rodent population which increases the plague reservoir.
Increased temperature and less rainfall causes an increased mortality as there are increased plague outbreaks.