NPR

Question 1

Give an example of a LHRH agonist.

Answer 1

Goserelin Buserelin Triptorelin Leuprolife

Question 2

Give an example of a suicide inhibitor.

Answer 2

Exemestane

Question 3

Give an example of a competitive,reversible aromatase inhibitor.

Answer 3

Anastrozole

Question 4

What are the most important target genes for the ER transcription factor?

Answer 4

Progesterone receptor Cyclin D1 c-myc TGF-alpha

Question 5

What is the main progestin used for metastatic breast cancer?

Answer 5

Megestrol acetate

Question 6

Name a drug that is a pure anti-oestrogen, showing no oestrogen like activity at all.

Answer 6

Faslodex

Question 7

Women in which age range are targeted for breast cancer screening? How often are they asked to go for screening?

Answer 7

50-64 yrs (this is being extended to 70 yrs) Every 3 years

Question 8

Women in which age range are targeted for breast cancer screening? How often are they asked to go for screening?

Answer 8

50-64 yrs (this is being extended to 70 yrs) Every 3 years

Question 9

What does the aromatase complex consist of?

Answer 9

CYP450 heme containing protein,flavoprotein NADPH cytochrome P450 reductase.

Question 10

What is the most-commonly prescribed aromatase inhibitor drug?

Answer 10

Anastrazole (reversible)

Question 11

Name some + end capping proteins.

Answer 11

CapZ Gelsolin Fragmin/severin

Question 12

Name some – end capping proteins.

Answer 12

Tropomodulin Arp2/3

Question 13

Name some severing proteins.

Answer 13

Gelsolin ADF Framin/severin Cofilin

Question 14

Name some proteins involved in these processes.

Answer 14

Alpha-actinin Fimbrin Filamin Spectrin Villin Vinculin