Novel multiple sclerosis treatments

Question 1

What is the “big picture” in novel treatments for multiple sclerosis?

Answer 1

Targeting both adaptive immunity in the periphery and innate mechanisms in the CNS

Question 2

What is HERV-W?

Answer 2

• Human endogenous retrovirus
• HERV-W protein expressed in brain tissue of MS patients
• Binds to TLR4 => activates microglia
• Damages oligodendrocytes and axons
  => New therapeutic target in MS