MRI quantification of multiple sclerosis pathology Flashcards
What are the 3 reasons radiology is important in multiple sclerosis?
- Shorten the time to diagnosis
- Early treatment
- Optimize treatment and benchmark future candidates
What is the goal for MRI scans in multiple sclerosis nationwide?
Harmonization of MRI for clinics in line with international guidelines
What type of MRI scan shows best multiple sclerosis lesions?
T2-weighted FLAIR
Where are the multiple sclerosis lesions locations?
Optic nerve, cortical, spinal cord, periventricular, periventricular juxtacortical and infratentorial
What are the 2 types of multiple sclerosis measurements?
- Lesion count
2. Lesion volume
What are the emerging advanced MRI techniques for multiple sclerosis?
- Increased disease specificity
- Increased quantitative information
- Higher resolution
- Micro-environmental disease processes
=> possible for myelin imaging
What is needed for MRI techniques?
- Faster imaging
- More pleasant imaging (less sound, larger tunnel size)
- Reduced need for contrast agents (tissue deposition)
- Better contrast, resolution
- Increased specificity of MR findings
- Quantitative biomarkers
What type of radiography allows molecular imaging?
- PET (Positron-Emission-Tomography)
- Radiolabel = radioactive: isotope linked to a molecule of interest