MRI quantification of multiple sclerosis pathology

Question 1

What are the 3 reasons radiology is important in multiple sclerosis?

Answer 1

1. Shorten the time to diagnosis
2. Early treatment
3. Optimize treatment and benchmark future candidates

Question 2

What is the goal for MRI scans in multiple sclerosis nationwide?

Answer 2

Harmonization of MRI for clinics in line with international guidelines

Question 3

What type of MRI scan shows best multiple sclerosis lesions?

Answer 3

T2-weighted FLAIR

Question 4

Where are the multiple sclerosis lesions locations?

Answer 4

Optic nerve, cortical, spinal cord, periventricular, periventricular juxtacortical and infratentorial

Question 5

What are the 2 types of multiple sclerosis measurements?

Answer 5

1. Lesion count

2. Lesion volume

Question 6

What are the emerging advanced MRI techniques for multiple sclerosis?

Answer 6

• Increased disease specificity
• Increased quantitative information
• Higher resolution
• Micro-environmental disease processes
  => possible for myelin imaging

Question 7

What is needed for MRI techniques?

Answer 7

• Faster imaging
• More pleasant imaging (less sound, larger tunnel size)
• Reduced need for contrast agents (tissue deposition)
• Better contrast, resolution
• Increased specificity of MR findings
• Quantitative biomarkers

Question 8

What type of radiography allows molecular imaging?

Answer 8

• PET (Positron-Emission-Tomography)

- Radiolabel = radioactive: isotope linked to a molecule of interest