MRI quantification of multiple sclerosis pathology Flashcards

1
Q

What are the 3 reasons radiology is important in multiple sclerosis?

A
  1. Shorten the time to diagnosis
  2. Early treatment
  3. Optimize treatment and benchmark future candidates
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2
Q

What is the goal for MRI scans in multiple sclerosis nationwide?

A

Harmonization of MRI for clinics in line with international guidelines

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3
Q

What type of MRI scan shows best multiple sclerosis lesions?

A

T2-weighted FLAIR

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4
Q

Where are the multiple sclerosis lesions locations?

A

Optic nerve, cortical, spinal cord, periventricular, periventricular juxtacortical and infratentorial

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5
Q

What are the 2 types of multiple sclerosis measurements?

A
  1. Lesion count

2. Lesion volume

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6
Q

What are the emerging advanced MRI techniques for multiple sclerosis?

A
  • Increased disease specificity
  • Increased quantitative information
  • Higher resolution
  • Micro-environmental disease processes
    => possible for myelin imaging
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7
Q

What is needed for MRI techniques?

A
  • Faster imaging
  • More pleasant imaging (less sound, larger tunnel size)
  • Reduced need for contrast agents (tissue deposition)
  • Better contrast, resolution
  • Increased specificity of MR findings
  • Quantitative biomarkers
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8
Q

What type of radiography allows molecular imaging?

A
  • PET (Positron-Emission-Tomography)

- Radiolabel = radioactive: isotope linked to a molecule of interest

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