Novel anticoagulants Flashcards
1
Q
Give an example
A
Rivaroxaban
2
Q
What are the indications for use
A
- Prevent clot extension + recurrent in DVT + PE
- Prevent embolic complications (stroke) in AF + heart valve replacement
3
Q
What is the mechanisms of action
A
- Inhibits hepatic production of vit K (in its reduced form) dependant coagulation factors/cofactors.
Inhibits vitamin K epoxide reductase = prevent reactivation of vit K & coagulation factor synthesis.
4
Q
What are the side effects
A
Bleeding
- epistasis
- retroperitoneal haemorrhage
- peptic ulcers
- intra-cranial haemorrhage
5
Q
What are the contraindications
A
- immediate risk haemorrhage
- liver disease
- pregnancy
6
Q
What are the interactions
A
Inducers + inhibitors P450
Abx can increase anticoagulation
