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Immune Notes > Notes > Flashcards

Notes Flashcards

1
Q

Macrophage activate Th1 by

A

IL12

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2
Q

Th1 activate the macrophage by

A

IFN-gamma

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3
Q

Th1 activate CD8 by

A

IL2

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4
Q

Macrophage activation lead to formation of

A

Granuloma

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5
Q

Which cell present in acute inflammation

A

Neutrophils

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6
Q

Which cell present in chronic inflammation

A

Macrophage

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7
Q

The main cells in granuloma

A

1.Epitheloid cell
2. Macrophage
3. Fibroblast
4. Lymophocytes

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8
Q

Class switching induce by which IL ?

A

IL4 IL5

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9
Q

Th1 inhibit Th2 by

A

IFN gamma

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10
Q

Th2 inhibit TH1 by

A

IL4,10

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11
Q

Macrophage in kidney called :

A

Mesangial cell

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12
Q

Macrophage in skin called :

A

Lingerhans cell

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13
Q

Macrophage in lungs called :

A

Alveolar macrophage

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14
Q

Macrophage in brain called :

A

Microgilial cell

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15
Q

Macrophage in tissue called :

A

Histiocytes

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16
Q

Macrophage in liver called :

A

Kupffer cell

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17
Q

Macrophage in intestinal wall called :

A

M-cell

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18
Q

Macrophage in bone called :

A

Osteoclast

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19
Q

Macrophage in spleen called :

A

Sinusoidal lining cell

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20
Q

Macrophage in placenta called :

A

Hofbauer cell

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21
Q

Inhibitory (anti-inflammatory )cytokines

A
  1. IL10
  2. TGF-Beta
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22
Q

Ab consist to two chains

A
  1. Heavy
  2. Light
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23
Q

Ab divided to ___&___ by ___ enzyme .

A

Fab, fc portion, by IgA protease

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24
Q

Between the fab and fc-portion found bound called

A

Disulfied bound

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25
Q

The constant portion of fab determined the

A

Ig istotype :M,A,G,E,D

26
Q

Isotype switching occurs in which area of lymphnode ?

A

In cortex in the follicle in Germinal center

27
Q

Two precess occurs in the germinal center of the lymphnode cortex (in follicle)

A
  1. Somatic hyper-maturation
  2. Isotype switching
28
Q

Which immune globulin present in primary (acute) immune response

A

IgM

29
Q

Which immune globulin present in secondary (chronic) immune response

A

IgG

30
Q

Half life of IgG

A

21 days

31
Q

Opsonisation of bacteria by

A
  1. IgG
  2. C3b
32
Q

Which immunoglobulin cross the placenta and provide passive immunity to infant ?

A

IgG

33
Q

Shape of IgG

A

Monomer

34
Q

Shape of IgA

A

Dimer

35
Q

Which Ig prevent attachment of Ag to mucous membrane of GIT and respiratory tract

A

IgA

36
Q

Two IgA binding together by which protein ?

A

j-chain

37
Q

How much protein have secretory IgA ?

A

*10
4 heavy chain, 4 light chain connected together by j-chain =9 +1 (secretory particle )

38
Q

Which disease characterised by : diarrhrea, gas , foal,smelling, stomach cramps or pain

A

Giardiasis

39
Q

IgA located in

A
  1. Mucosa
  2. Brest milk
  3. Secretion (tears, saliva, mucus )
40
Q

IgA bitter than IgG why?

A

Because IgA prevent the virus to enter the body , but IgG attack the virus after entering the body

41
Q

IgA protease secrete by which bacteria

A
  1. Nesseria
  2. S.pneumonia
  3. H.influenza
42
Q

The biggest Ig

A

IgM

43
Q

Which Ig have pentamer shape

A

IgM

44
Q

Pentamer meaning the Ig consist of

A

5 molecule

45
Q

Dimer meaning the Ig consist of

A

2 molecule

46
Q

Which Ig have the lowest concentration in the serum ?

A

IgE

47
Q

Which Ig have the high concentration in the serum ?

A

IgG

48
Q

Which cell present in case of warm infection

A

Eosinophils

49
Q

Eosinophils secrete ____ against warm

A

Major basic protein (MBP)

50
Q

IL6 in liver cause ____ and in hypothalamus cause ___.

A

Acute phase reactant , fever

51
Q

Absence of Decay accelerating factor lead to which disease ?

A

Paroxysmal nocturnal hemiglubinuria

52
Q

Absence of NADPH oxidase lead to

A

Chronic granulomatous disease ( recurrent infection )

53
Q

Which enzyme in phagosome when act for blue- green pigment

A

Myeloperoxidase

54
Q

IFN -alpha and Beta produce by which cells?

A

Virus-infected cells

55
Q

Super Ag cause

A

Septic shock

56
Q

Most common bacteria that cause septic shock

A
  1. S.aureus
  2. S.pyogenous
57
Q

Th1 inhibit Th2 by

A

IFN- gamma

58
Q

Th2 inhibit Th1 by

A

IL4,IL10

59
Q

which cell attack the candida ?

A

Neutrophils

60
Q

How Chemotherapy can increase the risk of candida infection ?

A

By ⬇️ neutrophils ( neutropenia )

61
Q

Septic (toxic) shock cause by which cells

A

Macrophage and T-cell

Immune Notes (4 decks)

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