Not high yield Flashcards
Apremilast
ANA - Dense Fine Speckled pattern (DFS70)
-Implication
Lower incidence of rheumatological disease
Are serial HRCTs useful in systemic sclerosis monitoring?
Regular CTs not helpful as any change manifests itself on PFTs
- can repeat if there’s a specific indication
Basic Calcium Phospate Hydroxyapatite Disease
Biosimilars
Histopathological and Immunopathological findings of GCA
In whom is ANCA testing indicated?
- Glomerulonephritis, especially RPGN
- Pulmonary haemorrhage, especially pulmonary-renal syndrome
- Cutaneous vasculitis, especially with systemic features
- Multiple lung nodules
- Chronic destructive disease of upper airways
- Long standing sinusitis or otisis
- Subglottic tracheal stenosis
- Mononeuritis multiplex or peripheral neuropathy
- Retro-orbital mass
In the above ANCA + PR3/MPO sens 86%, spec 99% for vasculitis
Myositis autoantibodies (part 2) = associaiton and implication
AntiTIF gamma
AntiNXP2
AntiMDA5
AntiSAE1
Myositis Autoantibodies = association and implication
- AntiMi2
- AntiJo1
- AntiKu
- AntiPM-Scl
- AntiSRP
- Anti-TRIM21 (Ro52)
PTPN22 polymorphism is associated with that rheum condition?
Risk factors for the development of lymphoma in Primary Sjogren’s
Inc risk of B cell lymphoma
Stickler syndrome
- Inheritance
- Defect
- Phenotype
What is Charles Bonnet syndrome
What is tubulointerstitial nephritis with uveitis syndrome?
- *Systemic autoimmune disease of unknown aetiology**
- <5% of all AIN. M:F 1:3, median onset 15yrs
Typically self limiting in children and relapsing in adults
Lymphocyte predominent interstitial nephritis + painful anterior uveitis
- ocular preced/accompany ARF (AKI) in 1/3
- associated with fever, anorexia, weight loss, abdominal pain, arthralgia
Ix
- sterile pyuria, mild proteinuria, Fanconi’s syndrome, increased ESR
- diagnosis of exclusion after ruling out: Sjogren’s, Behcet’s, sarcoidosis, SLE
Treatment
- Glucocorticoids +- maintenance with methotrexate, azathioprine, MMF
What are the non-typical antibodies that can cause ANCA positivity?
C-ANCA
- bactericidal permeability increasing protein causes atypical staining
P-ANCA
- Lactoferrin, elastase, cathepsin G, HMG proteins
