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Rheumatology > FRACP questions > Flashcards

FRACP questions Flashcards

1
Q

Leflunomide

A
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2
Q

Raynauds primary vs secondary

What has the highest negatiev predictive value for primary Raynauds?

A

Nailfold capilloroscopy!

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3
Q

Serum markers with strong association with disease activity in both GCA and PMR?

A

BAFF and IL-6

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4
Q

Secukinamab (novel anti IL-17A mab) is useful in which condition?

A
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5
Q

Febuxostat in comparison to allopurinol

A

More potent!

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6
Q

What is involved in the breakdown of cartilage in OA?

A

Aggrecanase

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7
Q

Giant cell arteritis - posisble role of which immunotherapy?

A

Tocilizumab ( IL-6 receptor inhibition)

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8
Q

IBM

A
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9
Q

Difference between IBM and polymyositis

A
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10
Q

Gout management in patient with acute flare 5 days ago

A
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11
Q

What risk factor causes gout by enhancing crystal formation?

A

Osteoarthritis!

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12
Q

Drug induced lupus serology - most specific Ab?

A

Antihistone Ab!

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13
Q

Anti-synthetase syndrome

A
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14
Q

Mandatory features for diagnosis of PMR

A
  1. Age >50
  2. Bilateral shoulder ache
  3. abnormal CRP +/- ESR
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15
Q

Timeline of malignancy risk in dermatomyositis. within what time frame?

A
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16
Q

What is the highest risk factor for developing scleroderma?

A

Positive family history

17
Q

What organ involvement is RARE in limited scleroderma?

A

Renal and cardiac - RARE in scleroderma

Lung dz 30%

Pulmonary HTN 10%

18
Q

What is the hallmark feature of diffuse scleroderma?

A

Tendon friction rubs!

Present in 62% of patients with diffuse and only 9% in limited

19
Q

What is the most common feature of limited scleroderma?

A

Telangiectasia!

Occurs in 91% of cases

20
Q

What is the most common immunological marker for renal crisis in diffuse scleroderma?

A

Anti-RNA polymerase III

Anti-RNA polymerase III isassociated with diffuse cutaenous disease and is the most common immunological marker for renal crisis.

21
Q

What is the most common histology of interstitial lung disease in systemic sclerosis?

A

Non-specific interstitial pneumonia

NSIP is the MOST COMMON pattern in systemic sclerosis and responds to treatment with cyclophosphamide

22
Q

What is the most common gastrointestinal effect in scleroderna?

A

Oesophageal reflux! Present in 90%

23
Q

Treatment options for ILD in scleroderma

A
  • First line: mycophenolate 3 g/day1or if intolerant, mycophenolic acid (720mg three times daily).
  • Oral or IV cyclophosphamide 500-750 mg/m2for 6-12 months followed by MMF or azathioprine for severe or progressive disease unresponsive to MMF2

Rheumatology (8 decks)

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