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MM TP2 > Normal tissue sensitivity > Flashcards

Normal tissue sensitivity Flashcards

1
Q

dose constraint for the brain?

A

max dose: 50Gy

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2
Q

What is the toxicity end point for the brain?

A

Symptomatic necrosis
Reduced cognitive development in children receiving whole- brain RT

Brain very sensitive to more than 2Gy per fraction and twice daily treatment

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3
Q

Is the brain a serial or parallel structure?

A

Parallel

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4
Q

What is the alpha beta ratio of the brain?

A

2.9

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5
Q

What is the dose constraint for the optic chiasm?

A

Max dose: 55Gy

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6
Q

Toxicity end point for the optic chiasm?

A

Potential for partial visual loss on section of optic nerve receiving dose

Optic neuropathy

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7
Q

Is the optic chiasm serial or parallel?

A

serial

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8
Q

What is the dose constraint for the brain stem?

A

Whole brainstem can receive no more than 54GY

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9
Q

Is the brain stem serial or parallel?

A

Serial

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10
Q

What is the toxicity end point for the brain stem?

A

Permanent cranial neuropathy or necrosis

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11
Q

What is the alpha beta ratio for the brain stem?

A

2.5-3.3

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12
Q

Max dose for the spinal cord?

A

Max dose: 45Gy it actually says 50 Gy in QUANTEC

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13
Q

What is the toxicity end point for the spinal cord?

A

Myelopathy

0.2% myelopathy with 50Gy (2Gy/#)

6% mylelopathy with 60Gy (2Gy/#)

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14
Q

Is the spinal cord serial or parallel?

A

serial

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15
Q

Alpha beta ratio for the spinal cord?

A

0.87

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16
Q

Max dose to the salivary glands?

A

Single parotid limit of 20Gy

Both parotids linnet of 25Gy
Submandibulars limit to 35Gy to help

DVH’s not reliable as GLANDS SHRINK DURING TREATMENT and gland sparing decreases

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17
Q

Toxicity end point for the salivary glands?

A

Long term parotid salivary function reduced.

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18
Q

are the salivary glands serial or parallel?

A

Parallel

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19
Q

Larynx and Pharynx dose constraint?

A

Absolute limit of 66Gy

40-45Gy if larynx is not the target structure

20
Q

Toxicity end point for the larynx and pharynx?

A

Pharynx: Dysphagia
Larynx: Vocal dysfunction, Oedema, Aspiration

21
Q

Dose constraint for the lung?

A

V20 limit 30-35%

22
Q

What is the toxicity end point for the lung?

A

Fibrosis (a/b 3.5)

Pneumonitis (a/b 4)

23
Q

Is the lung serial or parallel?

A

Parallel

24
Q

What is the alpha beta ratio for the lung?

A

3.5-4

25
Q

What is the dose constraint for the heart?

A

V25Gy

26
Q

What are the toxicity end points of the heart?

A

Long term Cardiac mortality

Diffuse myocardial fibrosis

Pericarditis

27
Q

Is the heart serial or parallel?

A

Mixed serial/parallel

28
Q

What is the max dose for the oesophagus?

A

40-50Gy to limit acute oesophagitis

29
Q

Toxicity end point for the oesophagus?

A

Oesophagitis – grade 3 acute

30
Q

Is the oesophagus serial or parallel?

A

Parallel

31
Q

What is the dose constraint for the liver?

A

Whole liver (mets) 30Gy

Primary liver: 28Gy

32
Q

Toxicity end point for the liver?

A

Radiation induced liver disease

33
Q

Is the liver serial or parallel?

A

Highly parallel

34
Q

Dose constraint for the small bowel and stomach?

A

Hard to delineate with contrast

50Gy limit

15Gy <120 cc (cubic centimeters) – which is 120 mL

35
Q

Toxicity end point for the stomach and small bowel?

A

Ulceration

Grade 3+ toxicity

36
Q

Are the stomach and small bowel serial or parallel?

A

Serial

37
Q

Bladder dose constraints?

A

V80 <15%
V75< 25%
V65 <50%

38
Q

Is the bladder serial or parallel?

A

Mixed-parallel

39
Q

What is the toxicity end point for the bladder?

A

Grade 3+ toxicity

40
Q

What are the dose constraints for the rectum?

A

V50Gy < 50%
V70Gy < 20%
V75Gy < 15%

41
Q

Toxicity end point for the rectum?

A

Grade 3+ late rectal toxicity

42
Q

Is the rectum serial or parallel?

A

Serial/Parallel

43
Q

What are the dose constraints for the penile bulb?

A

D90

D60-70

44
Q

What is the toxicity end point for the penile bulb?

A

Severe erectile dysfunction

45
Q

Is the penile bulb serial or parallel?

A

Parallel

MM TP2 (10 decks)

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