Normal Heme 1&2 Flashcards
Three major components of hemostatic system:
- Endothelium and sub-endothelium
- Platelets
- Coagulation cascade + fibrinolytic system
Endothelial contribution to bleeding and hemostasis:
Anti-thrombotic effects in normal tissue:
release of PROSTACYCLIN and NO
Prostacyclin contribution to bleeding and hemostasis:
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NO contribution to bleeding and hemostasis:
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Role of endothelium in regulating the hemostatic process
regulates hemostatic-coagulation via specific mediators released- antithrombic and pro-thrombic
Anti-thrombic (3 mechanisms):
1. antiplatelet (prostacycline and NO) preventing platelets and coagulation factors from coming into contact with subendothelium + vasodilation
2. anticoagulation:
- heparin-like molecule 2 + antithrombulin (anticoag)
- releases thrombomodulin – + thormbin -> activates pro C
- Protein S released from endo, cofactor for proC activaiton
PROTEIN C- activated, negativelyinfluences the thrombic cascade by lysing factor Va and factor VIIIa
3. Fibrolytic effects:
plasminogen activators (tPA), plasminogen –> plasmin = dissolves clot
What is primary hemostasis
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Function of platelets in primary hemostasis
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Explain platelet-collagen interaction
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Explain platelet adhesion
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Explain platelet aggregation
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Explain platelet release reaction
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Explain the interaction of platelet and endothelial cells and how this relationship may contribute to the development of thrombotic disorders.
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What is the intrinsic pathway?
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What test would you use to diagnose for disorders within the intrinsic pathway?
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What is the extrinsic pathway?
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