normal Flashcards
6000 l/day
250-300 g
LV s 1.5 cm thick atria .2 RV 0.5
starling’s law heart pumps out al the VR gien to it
Left ventricular myocytes are arranged circumferentially
in a spiral orientation that helps to generate
a coordinated wave of contraction that spreads from the
apex to the base of the heart
muscle histology
striation, central nucleus, sarcolemma, mitochodria,sarc. reticulum
AV tricuspid
mitral
13 and 11
semilunar 8 pulmonary and 6 aortic
Heart failure
With excessive dilation, the overlap of the actin and myosin
filaments is reduced and the force of contraction decreases
sharply, leading to heart failure
arrythmias
coordinated beating of cardiac myocytes depends
on intercalated discs(intrcellular junctions)
Within the intercalated discs (and at the lateral
borders of adjacent myocytes), gap junctions facilitate synchronized
waves of myocyte contraction by permitting
rapid movement of ions (e.g., sodium, potassium, calcium)
between adjoining cells
Abnormalities in the spatial distribution
of gap junctions in a variety of heart diseases can
cause electromechanical dysfunction
VALVES(FSV)
Lined by endothelium and have
a tri-layered structure
• A dense collagenous core (fibrosa) at the outflow
surface and connected to the valvular supporting
structures
• A central core of loose connective tissue (spongiosa)
• A layer rich in elastin (ventricularis or atrialis depending
on which chamber it faces) on the inflow surface