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Membranes And Receptors > Noradrenaline > Flashcards

Noradrenaline Flashcards

1
Q

Which enzyme is needed for NA synthesis?

A

Dopamine beta hydroxylase

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2
Q

What is the role of dopamine beta hydroxylase?

A

Coverts dopamine into NA

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3
Q

What molecule helps to package NA into vesicles?

A

VMAT

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4
Q

What is NA ultimately derived from?

A

Tyrosine

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5
Q

How does NA inhibit further release of NA?

A

Auto-inhibitory feedback

Binds to NET on presynaptic neuron

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6
Q

NA acts on which receptors in the heart?

A

Beta 1 and beta 2 adrenoceptors

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7
Q

Beta 1 and beta 2 adrenoceptors of the heart are associated with what type of G protein?

A

Gs

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8
Q

What does cocaine do?

A

Inhibits the reuptake of NA into the presynaptic neurone

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9
Q

How is NA removed from the cleft?

A

Reuptake (NET)
Uptake into cells in vicinity
Enters capillaries
Enzyme degradation

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10
Q

What are the 2 major enzymes for deactivation of NA?

A

COMT

MAO

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11
Q

What are the principal end products of NA degradation?

A

VMA

MHPG

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12
Q

When is VMA released?

A

Times of physical stress

From some tumours

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13
Q

What are low levels of MHPG connected to?

A

Anorexia nervosa

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14
Q

Does adrenaline have a greater affinity for alpha or beta adrenoceptors?

A

Beta

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15
Q

What type of drug is usually used for antihypertensive therapy?

A

Alpha or beta adrenoceptor antagonist

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16
Q

What is alpha-methyltyrosine?

A

Inhibitor of tyrosine hydroxylase

Inhibitor of catecholamine synthesis

17
Q

What is alpha-methyldopa?

A

A false substrate for DOPA decarboxylase
Therefore NA cannot be formed
Can be used as an antihypertensive therapy

18
Q

What is guanethidine?

A

Noradrenergic neurone blocking drug
Reduces cardiac output
Competes with NA to build up in vesicles

19
Q

What are the major side effects of guanethidine?

A

Postural hypotension
Sexual dysfunctions
Diarrhoea

20
Q

Where is NA released?

A

Postganglionic neurones of sympathetic NS

Membranes And Receptors (14 decks)

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