Effector Mechanisms

Question 1

When cAMP increases in the cell, what happens to PKA?

Answer 1

Dissociation of regulatory and catalytic subunits

Catalytic subunit activated - free to phosphorylate substrates

Question 2

What can activate PKC?

Answer 2

DAG

Ca2+

Question 3

What are the 2 subunits of PKA?

Answer 3

R - regulatory

C - catalytic

Question 4

What is a postive inotropic effect?

Answer 4

Increasing the force of contraction of the heart

Question 5

Which ligand and receptor has a positive inotropic effect?

Answer 5

Adrenaline/NA

Beta 1 adrenoceptors

Question 6

Increasing intracellular calcium into the heart increases…

Answer 6

Contractility

Question 7

All smooth muscle contraction utilises which G protein?

Answer 7

G alpha q

Question 8

How does morphine prevent neurotransmitter release?

Answer 8

Activates G alpha i proteins
The beta-gamma subunit binds to VOCC
Inhibits the channels so it is harder for Ca2+ to enter the cell therefore less stimulus for neurotransmitter release