Non Surgical treatment of Small Cell Lung Cancer Flashcards
SCLC doubling time?
29 days
CRT curative treatment? What combo of drugs? Do they do prophylactic brain radiation?
V V V Rare to do surgery as simply usually not caught early enough.
usually “curative” treatment is chemoradiotherapy eg cisplatin+etoposide. Often followed by prophylactic cranial radiation as they’re small cells (clue in the name) so can cross the blood-brain barrier.
If come in v early can combine Chemotherapy and immunotherapy in first line but usually not fit.
What is the response rate to SCLC treatment in early stages? Complete remission in what? Improves median survival from what to what?
Response rate = 90%
Complete remission 60%
No treatment median survival = 8 months
With treatment = 16 months
If extensive how do you treat? What is the response rate? Complete response rate? Improvement in median survival?
Combination therapy again, 4 cycles, posibility for radiotherapy for original sites of disease
Response rate = 80%
Complete response rate = 30%
Improvement in median survival from 8 weeks to 8 months with treatment
Chemotherapy side affects
Marrow suppression (+ risk of life threatening infection)
Neutropaenic sepsis
Nausea. Vomiting. GI upset. Mucositis. Fatigue. Lethargy.
Neuropathy. Increased risk MI/stroke. Renal impairment.
Hair loss. Nail changes
radiotherapy side effects
General: Lethargy. Risk to surrounding organs
Acute: pneumonitis. Dysphagia
Late: Fibrosis. Stricture. Increased risk MI. 2nd malignancies
Immunotherapy side effects
(anything-itis)
Commonly: colitis, pneumonitis, dermatitis, endocrinopathies
Who would lung cancer screening be made available to?
Mainly those at risk eg smokers. Wanting to balance the radiation risk from the scans with the advantages. Hope to make smokers aware of the increased risk that they are putting themselves at.
