Non-Psychotropic Medications in Psychiatry

Question 1

Give examples of antimuscarinics

Answer 1

1. Procyclidine
2. Benztropine
3. Trihexyphenidyl
4. Atropine (ophthalmic)

Question 2

What is the mechanism of action of antimuscarinics?

Answer 2

These medications block muscarinic acetylcholine receptors
→ This prevents the binding of acetylcholine
→ Reduce cholinergic activity in the CNS and periphery

Question 3

What are the uses of antimuscarinics in psychiatry?

Answer 3

1. Acute dystonia
2. Parkinsonism
   …
   (note: not tardive dyskinesia!)

Question 4

What are the side effects of antimuscarinics?

Answer 4

1. Dry mouth
2. Blurred vision
3. Constipation
4. Urinary retention
   …
5. Cognitive impairment (especially in older adults)
6. Worsening of tardive dyskinesia
7. Potential for misuse (euphoria at high doses)