Cannabinoids

Question 1

Where are cannabinoid receptors found?

Answer 1

1. Basal ganglia
2. Hippocampus
3. Cerebellum
4. Lower concentrations in the cerebral cortex
   …
   (note: this receptor is not found in the brainstem, a fact consistent with cannabis’ minimal effects on respiratory and cardiac functions)

Question 2

What is the mechanism of action of THC (delta-9-tetrahydrocannabinol)?

Answer 2

THC is a partial agonist which:
1. Binds to CB1 receptors in the CNS
2. Binds to CB2 receptors in the immune cells and peripheral tissues
….
This modulates the release of neurotransmitters such as:
1. Dopamine
2. GABA
3. Glutamate
4. Serotonin

Question 3

What is the mechanism of action of CBD (cannabidiol)?

Answer 3

THC is a weak agonist which:
1. Binds to CB1 receptors in the CNS
2. Binds to CB2 receptors in the immune cells and peripheral tissues
….
This modulates the release of neurotransmitters such as:
1. 5-HT1A receptors (anxiolytic effect)
2. TRPV1 and adenosine receptors