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Pain Medicine > Non-opioid Pharmacology > Flashcards

Non-opioid Pharmacology Flashcards

1
Q

Which NSAID is most common to cause liver failure

A

Sulindac

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2
Q

What pain syndrome is valproic acid indicated for

A

Migraine prophylaxis

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3
Q

Which has lower side effects - amitriptyline or nortriptyline

A

Nortriptyline - less anticholinergic effects, less sedation, less orthostatic hypotension.

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4
Q

2 medications used for trigeminal neuralgia

A

Carbamazepine (Tegretol) and oxcarbazepine (Trileptal)

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5
Q

What medication has side effect of agranulocytosis

A

Carbamazepine

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6
Q

What does gabapentin and pregabalin act on?

A

Calcium channels

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7
Q

Max daily dose recommended for APAP

A

<3g/day

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8
Q

MOA of lamotrigine, carbamazepine, oxcarbazepine

A

Inhibits voltage dependent sodium channels

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9
Q

MOA of valproic acid

A

Increases GABA effects and inhibits NMDA/glutamate receptors

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10
Q

Class of drugs of each of the following:

Duloxetine, fluoxetine, venlafaxine, citalopram, escitalopram, sertraline, paroxetine,

A

Venlafaxine and duloxetine are SNRIs. The rest are SSRIs.

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11
Q

Cardiovascular side effect of TCAs

A

QT prolongation

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12
Q

What step of the inflammatory pathway do NSAIDs inhibit

A

Conversion of arachadonic acid to prostaglandins

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13
Q

Which NSAIDs are least selective for COX-2

A

Ketorolac and Indomethacin

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14
Q

What does imipramine metabolize into

A

Desipramine

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15
Q

What medication has a side effect of toxic epidermal necrolysis

A

Lamotrigine

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16
Q

Moa of TCAs

A

Serotonin and norepinephrine reuptake inhibitor

17
Q

What does amitriptyline metabolize into

A

Nortriptyline

18
Q

Which NSAIDs have most COX-2 selectivity

A

Meloxicam and celecoxib

19
Q

What 4 things is duloxetine FDA approved for?

A

Diabetic peripheral neuropathic pain, fibromyalgia, anxiety, depression. Duloxetine = cymbalta

20
Q

Where does acetaminophen act on?

A

Does not act peripherally, it acts only in the CNS

Pain Medicine (10 decks)

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