Non-opioid Analgesics Flashcards
What is local inflammation?
The body’s response to an injury
- ID the injury
- remove noxious materials
- ward off infection
- repair damage to tissue/restore function
Injured cells release what?
Alarmins
T/F - pathogens can sneak through an injury site?
True
Alarmin Il-33 can produce what?
Degranulation of mast cells
Histamine
One of the more important initial mediators of the inflammatory response released by mast cells
How does Histamine act?
Through a GPCR to produce vasodilation and render the capillaries ‘leaky’
This allows more immune cells to enter the injury site and produce edema
What is Histamine-H1 receptors activity
Increase intracellular Ca to produce two major effects
What two major effects are the result of the increase of intracellular Ca by Histamine-H1 receptor activity?
1) NO mediated relaxation of smooth muscle, causing vasodilation
2) MLCK mediated contraction of the capilary endothelium
What does MLCK mediated contraction of the capillary endothelium cause?
It makes the capillaries leaky
As more immune cells are recruited to the injury site, what happens?
The inflammatory response is ramped up
What role does inflammation play in nociceptive pain?
Inflammatory mediators interact with receptors and facilitate the transmission of pain signals throughout the nervous system
What are the major inflammatory mediators that can cause pain?
Prostaglandins Substance P TNF-a IL-16 IL-6
T/F - Local inflammation adds to the pain felt at the injury site
True
T/F - Excessive inflammation is not beneficial to the host
True
What’s the goal of anti-inflammatory drugs?
Attenuate the inflammatory response
Attenuate pain