Non-opiod analgesics

Question 1

What are the non specific NSAIDS

Answer 1

diclofenac, ibuprofin, naproxen, ketoralac

Question 2

What specific NSAID do we need to know? What is it mechanism of actions

Answer 2

celecoxib (Celebrex). Acts on on COX2 enzymes

Question 3

What do prostaglandins do in the stomach? What happens when they are not being produced?

Answer 3

o Decrease secretion of H+
o Decrease secretion of pepsin
o Increase secretion of mucus
When not produced it can lead to GI bleed or peptic ulcer

Question 4

What do prostaglandins do in the kidneys? What happens when they are not being produced?

Answer 4

o Increase excretion of Na+ and water
o Increase excretion of free water
When they are not being produced it can lead to oliguria.

Question 5

What is an important fetal need for prostaglandins (It is why you can’t take ibuprofen of aspirin while pregnant)

Answer 5

The prostaglandins maintain the opening of the ductus arteriosus.