Non-Hodgkin's Lymphoma Flashcards
What is it?
A hetergeneous group of lymphoproliferative malignancies
What types are there?
Precursor B cell neoplasms, Mature B cell neoplasms, Precursor T cell neoplasms, Mature T cell neoplasms
Do they show any particular cells?
No, non-hodgkins DO NOT show reed sternburg cells
What is the most common type of non-hodgkins?
Diffuse Large B cell lymphoma
What is MALT?
Mucosa Associated Lymphoid tissue e.g lymphoid tissue in the gut
Is it common?
5 times more common than hodgkins
Who does it affect?
White people, median age onset 50 years old
Risk factors (9)
Chromosomal translocations, molecular rearrangements, EBV, Human T cell Leukaemia Virus Type 1, Hepatitis C, Pesticides, Herbicides, Radiation, Autoimmune disorders
Signs and Symptoms (8)
Painless lymphadenopathy, fatigue, weakness, fever, night sweats, splenomegaly, hepatomegaly, may have bowel obstruction
Differentials (4)
Hodgkins, Leukaemia, Metastatic malignancy, secondary to infection
What bloods would you do? (6)
FBC, U&E, LFT, Blood film, Viral serology, cytogenetics
Other investigations (8)
Chest xray, biopsy or fine needle aspiration, CT, Bone scans, MRI, USS, Bone marrow aspirate, LP
What is the treatment for low grade? (3)
Radio and chemotherapy, immunosuppressive therapy e.g Rituximab
What is the treatment for high grade? (3)
Chemo, immune therapy (rituximab), granulocyte colony stimulating factor
Complications (8)
Neutropenia, anaemia, thrombocytopenia, bleeding, cardiac metastases, SVC obstruction, GI obstruction, chemo-related complications
