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Pharm 2 (3rd Quarter) > Non-Depolarizers > Flashcards

Non-Depolarizers Flashcards

1
Q

NDNMBs act by

A

Combining with nicotinic cholinergic receptors without activation of ion channels

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2
Q

Tetanus and TOF give what data

A

Pre-junctional data

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3
Q

Single twitch response gives what data

A

Post-junctional

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4
Q

TOF fade aka

A

Wedensky inhibition

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5
Q

Wedensky inhibition is

A

Continuous refractory state preventing repolarization

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6
Q

NDNMB and volatile agents

A

NDNMB enhanced by volatile agents

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7
Q

Aminoglycosides and NDNMB fx

A

Enhance (Gent) via decreased prejx release of Ach and decreased post-jx sensitivity to Ach

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8
Q

Quinidine and NMB fx

A

Increases NDNMB and depolarizer function

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9
Q

2 categories of NDNMB

A

Aminosteroids (Roc and Vec)

Benzylisoquinoliniums (Nimbex)

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10
Q

3 characteristics of NMBs

A

Highly ionized

Water soluble at physiologic pH

Poorly lipid soluble

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11
Q

Plasma clearance, Vd, elimination 1/2 times influenced by (3)

A

Age

Volatile anesthetics

Hepatic/renal disease

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12
Q

Train of Four fade aka

A

Wedensky inhibition

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13
Q

LA effect on NDNMBs

A

Small dose- enhance

Large dose- block NM transmission

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14
Q

Effect of Dilantin on NMB

A

Increase depth of NMB

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15
Q

Ephedrine effect on NMB

A

Increases onset of NDNMB

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16
Q

Magnesium effect on NMB

A

Decrease onset and increase duration of action

17
Q

Respiratory acidosis and NDNMB

A

Augments NDNMB

18
Q

With severe hepatic dysfunction avoid

Use

A

Avoid Roc and Vec

Use Cistatracurium

19
Q

Roc and Vec are metabolized by

A

Liver

20
Q

Paraplegia/quadriplegia and NDNMB

A

Increased sensitivity

21
Q

Burns and NDNMB

A

Greater than 30% BSA burn get NDNMB resistance

22
Q

Hypokalemia and NDNMB

A

Smaller dose needed of NDNMD

Greater anticholinesterase needed for reversal

Pharm 2 (3rd Quarter) (6 decks)

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