Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharm 2 (3rd Quarter) > Anticholinergics > Flashcards

Anticholinergics Flashcards

1
Q

What are the 2 naturally occurring anticholinergics?

A

Atropine

Scopolamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Are naturally occurring anticholinergics tertiary or quaternary anticholinergics?

A

Tertiary

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Semi-synthetic anticholinergic

A

Glycopyrrolate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Is glyco tertiary or quaternary?

A

Quaternary

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Which class of anticholinergics cross BBB?

Ex.

A

Tertiary amine anticholinergics

Atropine and scopolamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Atropine and scopolamine are what mixture?

Active form?

A

Racemic mixtures

Levorotary exhibits anticholinergic effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Natural anticholinergics contain what acid?

A

Tropic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Semi-synthetic anticholinergics contain what acid?

A

Mandelic acid

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Anticholinergics work by

A

Fitting muscarinc cholinergic receptors just like Ach

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Anticholinergic =

A

Anti parasympathetic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Which exhibits greater antisialagogue and ocular effects?

A

Scopolamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Which anticholinergic works fastest?

A

Atropine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which anticholinergic would you give with edrophonium?

Which with neostigmine?

A

Edrophonium- atropine

Neostigmine- atropine or glycopyrrolate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Dose of atropine with edrophonium

A

7 mcg/kg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Dose of atropine with neostigmine

A

0.6-1.2 mg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Dose of glycopyrrolate with neostigmine

A

0.2-0.6mg

17
Q

Anticholinergics are specific to what receptors

A

Muscarinic

18
Q

Atropine Metabolism

A

30-50% excreted unchanged in urine

Hepatic metabolism results in tropic acid, groping, and glucuronide conjugated

19
Q

Does atropine cross BBB and placental barrier?

A

Yes

20
Q

Atropine terminal half life

A

2-3 hours

21
Q

Glycopyrrolate metabolism

A

Excreted as unchanged drug

22
Q

Which anticholinergic has most extensive metabolism

A

Scopolamine

23
Q

MOA of anticholinergic

A

Combine reversible with muscarinic cholinergic receptors and prevent Ach from binding

24
Q

Why scopolamine not combined with anticholinesterase for reversal of NDNMB

A

Pt would not wake up

25
Q

Which anticholinergic causes most sedative effects?

A

Scopolamine

26
Q

Which is most potent mydriatic anticholinergic and shouldn’t be given to glaucoma patients

A

Scopolamine

27
Q

CV implications with anticholinergics

A

Scop- decreases metabolic O2 requirements

Atropine- no change

Glyco- increases O2 needs

28
Q

Antisialagogue effects in order

A

Scop > glyco> atropine

29
Q

Drug of choice for treatment of central cholinergic syndrome and dose

A

Phyostigmine

15-60 mcg/kg

30
Q

Tx for anticholinergic OD

A

Phyostigmine 15-60 mcg/kg

31
Q

M1 receptors pharmacodynamics

A

Enhance cholinergic reflex bronchoconstriction

32
Q

M2 receptor pharmacodynamics

A

SA, AV,

Decreases myocardial O2 demands

Bronchodilator

GI

33
Q

M3 receptor pharmacodynamics

A

Bronchodilation, iris, ciliary body, GI

Pharm 2 (3rd Quarter) (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions