Non Alcoholic Fatty Liver Disease

Question 1

What is non alcoholic fatty liver disease (NAFLD)

Answer 1

Common liver disease and describes a spectrum of disease ranging from:
Steatosis (fat in the liver)
Steatohepatitis: fat with inflammation
Progression of disease can cause fibrosis and liver cirrhosis

Question 2

What is the mechanism of non alcoholic fatty liver disease

Answer 2

Insulin resistance that leads to steatosis

Question 3

What does insulin resistance do to the livr

Answer 3

Increase the fatty acid within the liver

Question 4

How is fatty acid in the liver increase

Answer 4

Lipolysis
Sratification of fatty acid into triglycerides which are deposited as fat droplets
Oxidation of FFA that leads to build up of reactive oxygen species

Question 5

What are the risk factors for non alcoholic fatty liver disease

Answer 5

Obesity
Childhood obesity
High calorie intake 
Type 2 diabetes 
Hyperlipidemia

Question 6

How to we manage non alcoholic fatty liver disease

Answer 6

Manage complications of cirrhosis
Liver directed pharmacoptherapy
Target components of metabolic syndrome: treat cholesterol, hypertension and diabetes
Lifestyle modification: lose weight

Question 7

In people with NASH how to we identify fibrosis

Answer 7

ELF Blood test

Question 8

If the patient is at risk of fibrosis whar happens

Answer 8

They are reffered to secondary scan for a fibroscan

Question 9

If the fibroscan score is more than 8 what is the next step

Answer 9

Liver biopsy

Question 10

If the ELF blod test is not available what are the other ways to investigate NALD

Answer 10

Fib4 score
Or
NALD fibrosis score