Nodular Hidradenoma

Question 1

Clinical appearance

Answer 1

Occurs as a solitary solid or cystic neoplasm

Question 2

Age of occurrence

Gender

Answer 2

4th to 8th decades of life

Female to male 2:1

Question 3

Prognosis

Answer 3

Recurrence, malignant transformation in metastatic spread have all been described in this tumor

Question 4

Origin of nodular hidradenoma

Answer 4

Rare benign sweat gland tumor

Question 5

Clinical appearance

Answer 5

Usually small, solitary, nodular, superficial dermal lesion with intact overlying skin
May also have ulceration or serous fluid leakage

Question 6

Where is this located

Answer 6

On the body primarily head, neck, torso

Histological within the dermis

Question 7

Malignancy

Answer 7

Malignant transformation has been sporadically reported in the literature

Question 8

Characteristics of malignancy

Answer 8

overt nuclear atypia
Abnormal mitosis
Infiltrated patterns
Lymphatic or perineural invasion
Necrosis

Question 9

IHC markers

Answer 9

Nodular hidradenoma
AE1/AE3
EMA
CEA
Malignant hidradenoma
PHH3 >0.7%
Ki – 67 > 11%

Question 10

Risk of recurrence

Answer 10

Risk of recurrence is reported as common up to 10%

Question 11

Management

Answer 11

High recurrence rate and potential malignancy of this tumor highlight the need for adequate treatment, complete excision of noular hidradrenoma with wide margins helps to prevent recurrence