Chemotherapy AEs

Question 1

What is the risk of bowel perforation with bev

Answer 1

11.4% in early phase II trial.

In larger phase III trial comparing cytotoxic chemo-therapy with or without bevacizumab showed that the inci-dence of GI perforation was higher in patients treated with bevacizumab (3 vs 1.2 %)

Question 2

Risk factors for bowel perforation

Answer 2

include a history of peptic ulcer disease, diverticulitis, colitis, intestinal obstruc-tion, tumor necrosis, recent sigmoidoscopy or colonoscopy, intact primary tumor, radiotherapy, higher cumulative dose of bevacizumab,

Question 3

Ascites is associated with what expression

Answer 3

VEGF expression