NOACs Flashcards
1
Q
Rivaroxiban
A
Xa inhibitor
reduced ICH
inc’d bleeding with with inhibitors of CYP3A4 - azoles, protease inhibitors, clarithromycin
DO NOT USE CrCl<30
2
Q
Apixiban
A
Xa inhibitor BID (5 or 2.5) 2.5 dose for 2/3 of: 1) Age>60 2) Wt < 60kg 3) Cr >1.5
Best with renal patients (75% fecal excretion)
3
Q
Edoxiban
A
Xa inhibitor
Do not use with NORMAL Cr Cl >95
4
Q
Dabigitran
A
reversible thrombin (IIa) inhibitor DO NOT USE CrCl<30
5
Q
NOACS and HIV
A
do not use for afib VTE ppx - interaction with protease inhibitors (levels of NOACs increase) - use warfarin
6
Q
Warfarin
A
Vit K antagonist (II, VII, IX, X)