NOACs Flashcards

1
Q

Rivaroxiban

A

Xa inhibitor
reduced ICH
inc’d bleeding with with inhibitors of CYP3A4 - azoles, protease inhibitors, clarithromycin
DO NOT USE CrCl<30

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2
Q

Apixiban

A
Xa inhibitor
BID (5 or 2.5)
2.5 dose for 2/3 of:
1) Age>60
2) Wt < 60kg
3) Cr >1.5

Best with renal patients (75% fecal excretion)

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3
Q

Edoxiban

A

Xa inhibitor

Do not use with NORMAL Cr Cl >95

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4
Q

Dabigitran

A
reversible thrombin (IIa) inhibitor
DO NOT USE CrCl<30
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5
Q

NOACS and HIV

A

do not use for afib VTE ppx - interaction with protease inhibitors (levels of NOACs increase) - use warfarin

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6
Q

Warfarin

A

Vit K antagonist (II, VII, IX, X)

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