NOAC Reversal Flashcards
What is the reversal agent for Dabigatran (Pradaxa)?
Idarucizumab (5 grams IV in 2 divided doses)
Idarucizumab specifically binds to Dabigatran, neutralizing its anticoagulant effect.
What laboratory tests are used to measure the effects of Dabigatran?
TT (Thrombin Time) / Hemoclot
These tests help assess the anticoagulant activity of Dabigatran.
How should Rivaroxaban and Apixaban be treated in case of overdose?
PCC (50 units/kg IV), TXA 1g, Andexanet alpha (not available in Australia), FEIBA, Recombinant factor Vila
These treatments help to reverse the effects of Xa inhibitors.
What is the preferred treatment for Dabigatran overdose?
PCC (50 units/kg IV), TXA 1g, Heamodialysis, Idarucizumab
Heamodialysis is effective for removing Dabigatran from circulation.
True or False: Dialysis is effective for reversing Xa inhibitors like Rivaroxaban and Apixaban.
False
Dialysis is not effective for Xa inhibitors.
What should be considered if there is a recent ingestion of anticoagulants?
Charcoal
Activated charcoal may be used to reduce absorption of the drug if administered shortly after ingestion.
Fill in the blank: The antidote for Dabigatran is _______.
Idarucizumab
Idarucizumab is specifically used for reversing the effects of Dabigatran.
What is the dosage of TXA recommended for both Dabigatran and Xa inhibitor overdoses?
1 gram IV followed by 1 gram infusion over 8 hours
TXA acts as an antifibrinolytic agent to help control bleeding.
What is FEIBA?
Factor eight inhibitor bypassing activity
FEIBA is used in hemophilia patients and can also be effective in reversing anticoagulant effects.
What is the main difference between Idarucizumab and Icatibant?
Idarucizumab is for Dabigatran reversal; Icatibant is for angioedema
Icatibant is a bradykinin receptor antagonist used in the treatment of angioedema.
