ITP/DIC/TTP Flashcards
What are common treatments for ITP?
- Steroids: 15-30mg/kg methylpred
- IVIG 1g/kg
- Plt transfusion 20ml/kg
- IV TXA 15mg/kg
- urgent surgical
These treatments aim to manage symptoms and improve platelet counts.
What is TTP and its primary defect?
Thrombotic Thrombocytopenic Purpura with an endothelial defect
TTP is a rare blood disorder that leads to the formation of small blood clots throughout the body.
What are the features of TTP?
- Ill-appearing
- Schistocytes
- Normal (slight increase) PT
- Normal (slight increase) PTT
- Normal Fibrinogen
- Normal (slight increase) D-dimer
These features help in diagnosing TTP.
What are common treatments for TTP?
- Plasma exchange
- Steroids: pred 1mg/kg/day
- rituximab
- splenectomy
Plasma exchange is critical in managing TTP.
What are the features of DIC?
- Ill-appearing
- Schistocytes
- Increased PT
- Increased PTT
- Decreased Fibrinogen
- Increased D-dimer
These findings indicate a hypercoagulable state and consumption of clotting factors.
What are common treatments for DIC?
Platelets
FFP 15ml/kg
Cryoprecipitate
Treatment focuses on addressing the underlying cause of DIC and managing symptoms.
Fill in the blank: In TTP, the PT is _______.
Normal (slight increase)
PT refers to Prothrombin Time, which measures how long it takes for blood to clot.
Fill in the blank: In DIC, the Fibrinogen level is _______.
Decreased
Fibrinogen is a protein essential for blood clotting.
What condition is characterized by antiplatelet antibodies?
ITP
The presence of antiplatelet antibodies leads to increased destruction of platelets.
How does thrombin excess relate to DIC?
Thrombin excess is a hallmark of DIC
This excess leads to increased clotting and subsequent consumption of clotting factors.
