NO2 reduction

Question 1

What happens in this reaction?

Answer 1

Oxygen is LOST (reduced) from the NO2, forming NH2,

Question 2

Why does the reaction occur?

Answer 2

To form a more polar compound that can now be metabolised via Phase 2 biotransformations.

Question 3

Where does the reaction occur and what conditions are needed?

Answer 3

Gut microflora, anaerobic conditions

Question 4

Give an example of a drug:

Answer 4

Nitrazepam