NNRTIs

Question 1

Efavirenz

Answer 1

NNRTIs

MOA: binds to RT, causes a conformational change and disrupt the catalytic center of the RT

Class AE: rash, hepatotoxic (increase LFT)
Special AE:
-CNS symptoms (vivid nightmares, “stoned”)
-Teratogenic

Class Interactions: CYP interactions
-mixed 3A4 inhibitor/inducer

Food: empty stomach
(high fat calorie diet increases abs –> increased AEs)

Question 2

Nevirapine

Answer 2

NNRTIs

MOA: binds to RT, causes a conformational change and disrupt the catalytic center of the RT

Class AE: rash, hepatotoxic (increase LFT)

Class Interactions: CYP interactions
-3A4 and 2B6 inducer

Food: take without regards to meal

Question 3

Etravirine

Answer 3

NNRTIs

MOA: binds to RT, causes a conformational change and disrupt the catalytic center of the RT

Class AE: rash, hepatotoxic (increase LFT)

Class Interactions: CYP interactions
-3A4 inducer
-2C9, 2C19 inhibitor

Food: take with food (increase absorption)

Question 4

Rilpivirine

Answer 4

NNRTIs

MOA: binds to RT, causes a conformational change and disrupt the catalytic center of the RT

Class AE: rash, hepatotoxic (increase LFT)

Class Interactions: NO CYP interactions!

Food: take with food (increase absorption)