Entry Inhibitor Flashcards
1
Q
Maraviroc
A
Entry Inhibitor
PO
MOA: CCR5-R antagonist –> blocks fusion and viral entry into the cell
–> Tropism test required
AE: Increase risk of infection
DDI: 3A4 inhibitors/inducers
(Maraviroc metabolized by 3A4)
2
Q
Enfuvirtide
A
Entry Inhibitor
SQ
MOA: Binds to gp41 –> blocks fusion and viral entry into cell
AE: Injection site reactions
3
Q
Ibalizumab
A
Entry Inhibitor
IV
MOA: mab against CD4 –> inhibit HIV from entering cells
USE: HIV with multi-drug resistance
AE:
diarrhea, dizziness
Immune reconstitution inflammatory syndrome (IRIS)
–> inflammatory response to opportunistic infections (MAC, CMV, PCP, TB)
