NMBD Reversal Agents

Question 1

What is neostigmine?

Answer 1

Anticholinesterase Inhibitor

Question 2

What is the reversal dosage of neostigmine?

Answer 2

0.04 - 0.07 mg/kg

OR

40 - 70 mcg/kg

Question 3

What is the maximum dosage of neostigmine?

Answer 3

80 mcg/kg

Question 4

What drug(s) should be given in conjunction with neostigmine?

Answer 4

Glycopyrrolate 0.2mg (per 1mg of neostigmine)

Question 5

What drug can be utilized to reverse non-depolarizing blockade?

Answer 5

Sugammadex (particularly rocuronium/vecuronium)

Question 6

What is the reversal dosing range of sugammadex?

Answer 6

2 - 16 mg/kg

Question 7

What type of drug is glycopyrrolate?

Answer 7

Anticholinergic

Question 8

Why is glycopyrrolate necessary with neostigmine reversal?

Answer 8

Glycopyrrolate will counteract the excessive cholinergic side effects of neostigmine administration.

Question 9

Is glycopyrrolate given before, in conjunction with, or after neostigmine administration?

Answer 9

Glycopyrrolate is given before neostigmine reversal.

Question 10

What is the max dose of glycopyrrolate?

Answer 10

1 mg