Nitroglycerin

Question 1

Mechanism of Action

Answer 1

• Vasodilator
• Nitrate
• Antianginal

Question 2

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Class

Answer 2

• Smooth muscle relaxant acting on vasculature, bronchial, uterine, and intesetinal smooth muscle
• Dialation of arterioles & veins in the periphery, reduces preload & afterload
• Decreases workload of the heart = decreases mycardial O2 demand

Question 3

Indication

Answer 3

• Ischemic Chest pain
• Pulmonary Edema
• CHF
• Acute and Symptomatic hypertension

Question 4

Contraindication

Answer 4

• Hypovolemia
• Instracranial bleeding/Head Injury
• Hypotension, SBP <100mmHg
• ED meds within 48 hours
• Right sided mycardial infarction

Question 5

Adverse Reaction/Side Effects

Answer 5

• Headache
• Dizziness
• Syncope/Weakness
• Dry Mouth
• Hypotention
• Reflex Tacycardia
• Flushing/Diaphoresis
• Nausea/Vomiting
• Muscle Twitching
• Hypersensitivity

Question 6

Dosage/Administration

Answer 6

• Tablet/Sublingual: 0.4mg, repeat every 3-5 minutes (max 3 doses)
• CHF/Pulomonary Edema: 0.4mg-1.2mg (SL) repeat every 5 minutes as long as patient’s SBP remains stable

Question 7

Duration of Action

Answer 7

Onset: 1-3 min
Peak: 5-10 min
Duration: 20-30min (1-10min after IV infusion)