Nitric Oxide & Related Drugs; L6 (9-30-15)

Question 1

~Nitric Oxide (INOMAX)

Answer 1

• MOA: covalent modification of proteins
• ROA: inhalation
• Indications: ACS (acute coronary syndrome)
• Side-effects: vasodilation

Question 2

Nitroglycerin

Answer 2

• MOA: NO donor (DILATION OF VEINS and ^ venous capacitance)
• ROA: sublingual
• Indications: pulmonary arterial hypertension (+ ANGINA; congestive heart failure; control of HTN)
• Side-effects: hypotension

Question 3

Hydralazine

Answer 3

• MOA: NO donor, vasodilator (arteriolar vasodilation)
• ROA: oral
• Indications: HTN
• Side-effects: headache, nausea, vomiting, hypotension

Question 4

Sildenafil (Viagra)

Answer 4

• MOA: phosphodiesterase inhibitor (VASCULAR SMOOTH MUSCLE RELAXATION)
• ROA: oral
• Indications: (PULMONARY ARTERIAL) hypertension; (ERECTILE DYSFUNCTION)
• Side-effects: hypotension, drug interactions (CANNOT be taken with nitroglycerin–potentiates VASODILATION and HYPOTENSION by activation of guanylate cyclase and huge increase in cGMP!)

Question 5

~L-Arginine

Answer 5

• MOA: NO donor
• ROA: oral
• Indications: ACS (acute coronary syndrome), vascular disease
• Side-effects: hypotension