Nitrates (-nitrate) Flashcards

1
Q

Examples

A
Glyceryl trinitrate (GTN)
Isosorbide dinitrate (ISD)
Isosorbide mononitrate (ISM)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

MoA

A

Endothelium derived relaxing factor receptor
Agonist
Reacts with -SH groups to release NO, stimulating guanylyl cyclase to dephosphorylate myosin light chain kinase and reduce [Ca2+]
Vasodilatation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Indications

A

GTN - Acute prophylaxis

ISD/ISM - Angina prophylaxis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

ADR

A

Headache, Flushing
Hypotension, Tachycardia
Methaemoglobinaemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Prescribing Advice

A

GTN low bioavailability
Nitrate tolerance reversed with ‘Nitrate-free interval’ or
-SH donors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly