Nitrates (-nitrate) Flashcards
1
Q
Examples
A
Glyceryl trinitrate (GTN) Isosorbide dinitrate (ISD) Isosorbide mononitrate (ISM)
2
Q
MoA
A
Endothelium derived relaxing factor receptor
Agonist
Reacts with -SH groups to release NO, stimulating guanylyl cyclase to dephosphorylate myosin light chain kinase and reduce [Ca2+]
Vasodilatation
3
Q
Indications
A
GTN - Acute prophylaxis
ISD/ISM - Angina prophylaxis
4
Q
ADR
A
Headache, Flushing
Hypotension, Tachycardia
Methaemoglobinaemia
5
Q
Prescribing Advice
A
GTN low bioavailability
Nitrate tolerance reversed with ‘Nitrate-free interval’ or
-SH donors